肥胖是由饥饿神经元周围分子网格的堆积所导致的。 - Suppr

Obesity is driven by a build-up of molecular mesh around hunger neurons.

作者信息

Dityatev Alexander

出版信息

Nature. 2024 Sep;633(8031):771-772. doi: 10.1038/d41586-024-02325-5.

DOI:10.1038/d41586-024-02325-5

PMID:39294280

Abstract

摘要

相似文献

Obesity is driven by a build-up of molecular mesh around hunger neurons.

Nature. 2024 Sep;633(8031):771-772. doi: 10.1038/d41586-024-02325-5.

Brain goop that traps hunger neurons drives obesity.

Nature. 2024 Sep;633(8031):752. doi: 10.1038/d41586-024-03025-w.

Pathogenic hypothalamic extracellular matrix promotes metabolic disease.

Nature. 2024 Sep;633(8031):914-922. doi: 10.1038/s41586-024-07922-y. Epub 2024 Sep 18.

Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons.

Nat Rev Drug Discov. 2012 Sep;11(9):675-91. doi: 10.1038/nrd3739. Epub 2012 Aug 3.

Adipose tissue depot-specific intracellular and extracellular cues contributing to insulin resistance in obese individuals.

FASEB J. 2020 Jun;34(6):7520-7539. doi: 10.1096/fj.201902703R. Epub 2020 Apr 15.

High-fat diet decreases energy expenditure and expression of genes controlling lipid metabolism, mitochondrial function and skeletal system development in the adipose tissue, along with increased expression of extracellular matrix remodelling- and inflammation-related genes.

Br J Nutr. 2015 Mar 28;113(6):867-77. doi: 10.1017/S0007114515000100. Epub 2015 Mar 6.

Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat.

Elife. 2020 Jul 28;9:e55909. doi: 10.7554/eLife.55909.

Insulin, ghrelin and early return of hunger in women with obesity and polycystic ovary syndrome.

Physiol Behav. 2019 Jul 1;206:252-258. doi: 10.1016/j.physbeh.2019.03.013. Epub 2019 Mar 17.

Perineuronal nets in neurodegeneration.

Oncotarget. 2016 Nov 29;7(48):78224-78225. doi: 10.18632/oncotarget.13420.

Pinpointing the neurons that signal hunger in mice.

Lab Anim (NY). 2015 Feb;44(2):43. doi: 10.1038/laban.694.

本文引用的文献

Linking epileptic phenotypes and neural extracellular matrix remodeling signatures in mouse models of epilepsy.

Neurobiol Dis. 2023 Nov;188:106324. doi: 10.1016/j.nbd.2023.106324. Epub 2023 Oct 12.

A comprehensive atlas of perineuronal net distribution and colocalization with parvalbumin in the adult mouse brain.

Cell Rep. 2023 Jul 25;42(7):112788. doi: 10.1016/j.celrep.2023.112788. Epub 2023 Jul 11.

A shift in the mechanisms controlling hippocampal engram formation during brain maturation.

Science. 2023 May 5;380(6644):543-551. doi: 10.1126/science.ade6530. Epub 2023 May 4.

Microglia-mediated degradation of perineuronal nets promotes pain.

Science. 2022 Jul;377(6601):80-86. doi: 10.1126/science.abl6773. Epub 2022 May 26.

Insulin action in the brain: cell types, circuits, and diseases.

Trends Neurosci. 2022 May;45(5):384-400. doi: 10.1016/j.tins.2022.03.001. Epub 2022 Mar 28.

Interplay between perivascular and perineuronal extracellular matrix remodelling in neurological and psychiatric diseases.

Eur J Neurosci. 2021 Jun;53(12):3811-3830. doi: 10.1111/ejn.14887. Epub 2020 Jul 25.

Perineuronal Net Formation during the Critical Period for Neuronal Maturation in the Hypothalamic Arcuate Nucleus.

Nat Metab. 2019 Feb;1(2):212-221. doi: 10.1038/s42255-018-0029-0. Epub 2019 Jan 21.

Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis.

Brain. 2018 Apr 1;141(4):1094-1110. doi: 10.1093/brain/awy033.

Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats.

Sci Transl Med. 2017 Dec 20;9(421). doi: 10.1126/scitranslmed.aai8753.

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination.

Nat Commun. 2016 Apr 26;7:11312. doi: 10.1038/ncomms11312.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验

Obesity is driven by a build-up of molecular mesh around hunger neurons.

作者信息

出版信息

相似文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

相似文献

本文引用的文献