肥胖是由饥饿神经元周围分子网格的堆积所导致的。 - Suppr

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Obesity is driven by a build-up of molecular mesh around hunger neurons.

作者信息

Dityatev Alexander

出版信息

Nature. 2024 Sep;633(8031):771-772. doi: 10.1038/d41586-024-02325-5.

DOI:10.1038/d41586-024-02325-5

PMID:39294280

Abstract

摘要

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Linking epileptic phenotypes and neural extracellular matrix remodeling signatures in mouse models of epilepsy.在癫痫小鼠模型中，连接癫痫表型和神经细胞外基质重塑特征。

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A comprehensive atlas of perineuronal net distribution and colocalization with parvalbumin in the adult mouse brain.成年小鼠大脑中神经周细胞网分布及其与帕伐洛米蛋白共定位的综合图谱

Cell Rep. 2023 Jul 25;42(7):112788. doi: 10.1016/j.celrep.2023.112788. Epub 2023 Jul 11.

A shift in the mechanisms controlling hippocampal engram formation during brain maturation.大脑成熟过程中控制海马体印痕形成的机制发生转变。

Science. 2023 May 5;380(6644):543-551. doi: 10.1126/science.ade6530. Epub 2023 May 4.

Microglia-mediated degradation of perineuronal nets promotes pain.小胶质细胞介导的周围神经毡降解促进疼痛。

Science. 2022 Jul;377(6601):80-86. doi: 10.1126/science.abl6773. Epub 2022 May 26.

Insulin action in the brain: cell types, circuits, and diseases.脑内胰岛素作用：细胞类型、回路和疾病。

Trends Neurosci. 2022 May;45(5):384-400. doi: 10.1016/j.tins.2022.03.001. Epub 2022 Mar 28.

Interplay between perivascular and perineuronal extracellular matrix remodelling in neurological and psychiatric diseases.神经和精神疾病中血管周和神经周细胞外基质重塑的相互作用。

Eur J Neurosci. 2021 Jun;53(12):3811-3830. doi: 10.1111/ejn.14887. Epub 2020 Jul 25.

Perineuronal Net Formation during the Critical Period for Neuronal Maturation in the Hypothalamic Arcuate Nucleus.弓状核神经元成熟关键期的周围神经毡形成

Nat Metab. 2019 Feb;1(2):212-221. doi: 10.1038/s42255-018-0029-0. Epub 2019 Jan 21.

Chondroitin sulfate proteoglycans as novel drivers of leucocyte infiltration in multiple sclerosis.硫酸软骨素蛋白聚糖作为多发性硬化症中白细胞浸润的新型驱动因素。

Brain. 2018 Apr 1;141(4):1094-1110. doi: 10.1093/brain/awy033.

Hippocampal extracellular matrix alterations contribute to cognitive impairment associated with a chronic depressive-like state in rats.海马细胞外基质的改变导致与大鼠慢性抑郁样状态相关的认知障碍。

Sci Transl Med. 2017 Dec 20;9(421). doi: 10.1126/scitranslmed.aai8753.

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