Chiang Chih-Chao, Cheng Wei-Jen, Dela Cruz Joseph Renz Marion Santiago, Raviraj Thiyagarajan, Wu Nan-Lin, Korinek Michal, Hwang Tsong-Long
Department of Nutrition and Health Sciences, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Puxin Fengze Chinese Medicine Clinic, Taoyuan, Taiwan.
Clin Rev Allergy Immunol. 2024 Dec;67(1-3):21-39. doi: 10.1007/s12016-024-09004-3. Epub 2024 Sep 18.
Neutrophils have a critical role in inflammation. Recent studies have identified their distinctive presence in certain types of atopic dermatitis (AD), yet their exact function remains unclear. This review aims to compile studies elucidating the role of neutrophils in AD pathophysiology. Proteins released by neutrophils, including myeloperoxidase, elastase, and lipocalin, contribute to pruritus progression in AD. Neutrophilic oxidative stress and the formation of neutrophil extracellular traps may further worsen AD. Elevated neutrophil elastase and high-mobility group box 1 protein expression in AD patients' skin exacerbates epidermal barrier defects. Neutrophil-mast cell interactions in allergic inflammation steer the immunological response toward Th2 imbalance and activate the Th17 pathway, particularly in response to allergens or infections linked to AD. Notably, drugs alleviating pruritic symptoms in AD inhibit neutrophilic inflammation. In conclusion, these findings underscore that neutrophils may be therapeutic targets for AD symptoms, emphasizing their inclusion in AD treatment strategies.
中性粒细胞在炎症中起关键作用。最近的研究已确定它们在某些类型的特应性皮炎（AD）中独特存在，但其确切功能仍不清楚。本综述旨在汇总阐明中性粒细胞在AD病理生理学中作用的研究。中性粒细胞释放的蛋白质，包括髓过氧化物酶、弹性蛋白酶和脂质运载蛋白，会促进AD中的瘙痒进展。中性粒细胞氧化应激和中性粒细胞胞外陷阱的形成可能会使AD进一步恶化。AD患者皮肤中中性粒细胞弹性蛋白酶和高迁移率族蛋白B1表达升高会加剧表皮屏障缺陷。过敏炎症中的中性粒细胞 - 肥大细胞相互作用会使免疫反应趋向于Th2失衡并激活Th17途径，特别是在对与AD相关的过敏原或感染作出反应时。值得注意的是，减轻AD瘙痒症状的药物可抑制中性粒细胞炎症。总之，这些发现强调中性粒细胞可能是AD症状的治疗靶点，突出了将它们纳入AD治疗策略的重要性。
