Qian Siyi, Zhou Yanhong, Jin Zhongyuan, Li Xiang, Tian Yuxuan, Chen Fuxin, Zhang Bin, Yan Zhipeng
The 2nd Department of Gynecology Oncology of Hunan Cancer Hospital the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, 410013, People's Republic of China.
Department of Histology and Embryology, Basic School of Medicine Sciences, Central South University, Changsha, Hunan, 410013, People's Republic of China.
Clin Rev Allergy Immunol. 2024 Dec;67(1-3):96-110. doi: 10.1007/s12016-024-09010-5. Epub 2024 Nov 29.
NKp46 is a natural killer cell activating receptor primarily expressed on NK cells and non-NK innate lymphoid cells. In the context of anti-infection, NKp46 activates NK cells by binding to ligands on pathogens or infected cells, enabling NK cells to kill the infected cells. In antitumor activities, NKp46 plays a pivotal role in combating tumor growth through mechanisms such as directly killing tumor cells, inhibiting tumor immune escape, and reducing tumor growth rate through immune editing. The expression levels of NKp46 are closely associated with the progression of immune-related diseases, viral infections, leukemia, tumors, and reproductive failure, affecting diagnosis and prognosis. However, the functionality and mechanistic actions of NKp46, as well as the identification of additional NKp46 ligands, require further investigation. This review provides a comprehensive understanding of NKp46, offering a theoretical foundation for the research and development of diagnostic and therapeutic approaches for related diseases.
NKp46是一种主要表达于自然杀伤细胞（NK细胞）和非NK固有淋巴细胞上的自然杀伤细胞激活受体。在抗感染的背景下，NKp46通过与病原体或受感染细胞上的配体结合来激活NK细胞，使NK细胞能够杀死受感染细胞。在抗肿瘤活性方面，NKp46通过直接杀死肿瘤细胞、抑制肿瘤免疫逃逸以及通过免疫编辑降低肿瘤生长速率等机制，在对抗肿瘤生长中发挥关键作用。NKp46的表达水平与免疫相关疾病、病毒感染、白血病、肿瘤及生殖功能衰竭的进展密切相关，影响诊断和预后。然而，NKp46的功能和作用机制，以及其他NKp46配体的鉴定，仍需要进一步研究。本综述全面介绍了NKp46，为相关疾病诊断和治疗方法的研发提供了理论基础。
