Rausch L
Z Lymphol. 1985 Jun;9(1):25-9.
According to the generally held view, objections in terms of radiation hygiene are less important in individually indicated mammographic investigations. Radiation protection in mammography is restricted to the carcinogenic side effect of radiation exposure in mass screening of asymptomatic women. A dose-proportional carcinogenic side effect independent of the dose distribution in time is also to be assumed in the small dose range. The International Radiation Protection Commission therefore requires a cost-benefit analysis to including costs for all mass X-ray examinations. It is indispensable to consider each age group separately in order to arrive at a rational and medically acceptable result. Cost/benefit analyses integrated over all age groups obscure important decision indicators with their positive results throughout. In a differentiated consideration, one arrives at a minimum age of entry for participation of asymptomatic women in regular mass screening. This depends on the dose requirement of the system used. The available recommendations tend to be restrictive in the case of relatively high dose requirement, and can be interpreted more extensively in the case of lower dose requirement. Inclusion of younger age groups with very low incidence which is possible in terms of risk criteria after a major lowering of the dose requirement leads to a low specific benefit and high specific costs, i.e. to a poor cost/benefit relation. Objections to the cost/benefit analyses undertaken could be shown to be based on the neglect of an age-differentiated consideration, one-sided selection of material, selective interpretation of the literature, inadmissible generalizations, the highlighting of relatively implausible assumptions, fundamental errors and argumentations colored by professional interest.(ABSTRACT TRUNCATED AT 250 WORDS)
根据普遍观点,在针对个体的乳腺钼靶检查中,从辐射卫生角度提出的反对意见不太重要。乳腺钼靶检查中的辐射防护仅限于无症状女性群体筛查中辐射暴露的致癌副作用。在小剂量范围内,还应假定存在与时间剂量分布无关的剂量成比例致癌副作用。因此,国际辐射防护委员会要求进行成本效益分析,其中要包括所有群体X线检查的成本。为了得出合理且医学上可接受的结果,分别考虑每个年龄组是必不可少的。对所有年龄组进行综合的成本/效益分析会掩盖整个过程中重要的决策指标及其积极结果。经过差异化考量,可以得出无症状女性参与定期群体筛查的最低年龄。这取决于所使用系统的剂量要求。在剂量要求相对较高的情况下,现有建议往往较为严格;而在剂量要求较低的情况下,则可以有更广泛的解释。在大幅降低剂量要求后,从风险标准来看,纳入发病率极低的年轻年龄组会导致特定效益低而特定成本高,即成本/效益关系不佳。对所进行的成本/效益分析的反对意见可能被证明是基于对年龄差异化考量的忽视、材料的片面选择、对文献的选择性解读、不可接受的概括、对相对不合理假设的强调、根本性错误以及受专业利益影响的论证。(摘要截取自250词)