Department of Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China.
School of Public Health, Gansu University of Traditional Chinese Medicine, Lanzhou, China.
Diabetes Obes Metab. 2024 Dec;26(12):5827-5835. doi: 10.1111/dom.15954. Epub 2024 Sep 18.
To determine if estimated glucose disposal rate (eGDR) can predict cardiovascular disease mortality risk at different levels of glycaemic tolerance.
The eGDR levels of 11 656 individuals aged 45-79 years from the National Health and Nutrition Examination Survey cycles 1999 to 2010 were analysed. Associations between eGDR levels and all-cause and cardiovascular mortality were examined using Cox proportional hazards and Fine and Gray models, respectively.
After a median follow-up of 12.8 years, a total of 2852 participants died, with 777 of those deaths attributed to cardiovascular causes. When comparing participants with eGDR values of ≤4 mg/kg/min to those with eGDR values falling within the ranges of 4-6, 6-8 and >8 mg/kg/min, it was found that the latter groups exhibited lower hazard ratios for both all-cause mortality (0.61 [0.52-0.72], 0.61 [0.52-0.72] and 0.46 [0.39-0.55]) and cardiovascular mortality (0.44 [0.33-0.57], 0.45 [0.34-0.59] and 0.30 [0.23-0.40]). A U-shaped relationship between eGDR and all-cause mortality was observed, with an inflection point at an eGDR of 9.54 mg/kg/min.
In the general population, the association between reduced eGDR and all-cause and cardiovascular mortality was independently significant, contributing to the identification of individuals at high risk for different levels of glucose tolerances.
确定估算的葡萄糖处置率（eGDR）是否可以预测不同血糖耐受水平的心血管疾病死亡率风险。
分析了 1999 年至 2010 年全国健康与营养调查周期中 11656 名 45-79 岁个体的 eGDR 水平。使用 Cox 比例风险和 Fine 和 Gray 模型分别检查 eGDR 水平与全因和心血管死亡率之间的关联。
中位随访 12.8 年后，共有 2852 名参与者死亡，其中 777 人死于心血管原因。与 eGDR 值≤4mg/kg/min 的参与者相比，eGDR 值处于 4-6、6-8 和>8mg/kg/min 范围内的参与者，发现后两组的全因死亡率（0.61[0.52-0.72]、0.61[0.52-0.72]和 0.46[0.39-0.55]）和心血管死亡率（0.44[0.33-0.57]、0.45[0.34-0.59]和 0.30[0.23-0.40]）的风险比均较低。eGDR 与全因死亡率之间呈 U 形关系，拐点在 eGDR 为 9.54mg/kg/min 时出现。
在一般人群中，eGDR 降低与全因和心血管死亡率之间的关联具有独立的显著性，有助于识别不同血糖耐受水平的高风险个体。
