Kong Fred K W, Wong April S Y, Cheung Raymond K K, Wan Terence S M, Ho Emmie N M
Racing Laboratory, The Hong Kong Jockey Club, Sha Tin Racecourse, Sha Tin, N.T. Hong Kong, China.
Drug Test Anal. 2025 Jul;17(7):1011-1027. doi: 10.1002/dta.3801. Epub 2024 Sep 18.
In order to control the potential misuse of perfluorocarbons as an oxygen carrier in equine sports, a simple and sensitive method for detecting perfluorocarbons in equine plasma by gas chromatography/tandem mass spectrometry using negative chemical ionization with methane as reagent gas has been developed and fully validated. The method covers seven perfluorocarbons, which are the active components in blood substitute products, and shows good sensitivity and robustness. Limits of detection as low as 0.01 ng/mL could be achieved by the method. To the best of our knowledge, this is the first report of a detection method for the screening of perfluorocarbons in equine biological samples.
为了控制全氟化碳在马术运动中作为氧载体的潜在滥用情况，已开发并全面验证了一种简单且灵敏的方法，该方法通过气相色谱/串联质谱法，以甲烷作为反应气采用负化学电离模式来检测马血浆中的全氟化碳。该方法涵盖了七种全氟化碳，它们是血液替代产品中的活性成分，并且具有良好的灵敏度和稳健性。该方法的检测限低至0.01 ng/mL。据我们所知，这是首篇关于马生物样本中全氟化碳筛查检测方法的报告。
