Department of Pharmacology, Faculty of Medicine, İstanbul Atlas University, İstanbul, Turkiye.
Turk J Med Sci. 2024 Apr 4;54(4):666-674. doi: 10.55730/1300-0144.5835. eCollection 2024.
BACKGROUND/AIM: It is critically important to protect the health of the oldest-old people, as their hospitalization and death rates are high. The objective of this study was to analyze the prevalence of potentially inappropriate medication use among the community-dwelling oldest-old people and its association with their demographic characteristics.
Data were collected from real-world settings using the observational method for this descriptive study. An older adult aged ≥ 85 years old was defined as the oldest-old. The participants were visited in their homes. The generic names of the medications used, and the age, sex, and province of residence were recorded. The medications were analyzed according to the 2019 Beers criteria, and their prevalence of use among the oldest-old people was determined.
Data were collected from 549 of the oldest-old people. The median age of the participants was 88.0 years (88.8 ± 3.5; min = 85.0, max = 102), and 61.3% (n = 336) of them were female. The study findings showed that 65.0% of the community-dwelling oldest-old people used potentially inappropriate medications, with a median number of 1 (min = 0, max = 6). The prevalence of potentially inappropriate medication use increased linearly with the number of drugs used (p = 0.001). The median number of medications was significantly higher in the potentially inappropriate medication user group (5 vs. 2, p = 0.001). Diuretics, proton pump inhibitors, and nonsteroidal antiinflammatory drugs were the most frequently used potentially inappropriate medications.
The prevalence of potentially inappropriate medication use was high among the oldest-old people in Turkiye. There were no differences in frequency of use according to age, sex, or geographical region. It is important to prevent the use of potentially inappropriate medications that should be avoided and to monitor the oldest-old group that uses potentially inappropriate medications that should be used with caution.
背景/目的：保护高龄老人的健康至关重要，因为他们的住院率和死亡率都很高。本研究旨在分析社区居住的高龄老人中潜在不适当用药的流行情况及其与人口统计学特征的关系。
本研究采用观察法从真实环境中收集数据，将年龄≥85 岁的老年人定义为高龄老人。对他们进行家访，记录所用药物的通用名、年龄、性别和居住省份。根据 2019 年 Beers 标准分析药物，并确定高龄老人中潜在不适当用药的使用情况。
共收集了 549 名高龄老人的数据。参与者的中位年龄为 88.0 岁（88.8 ± 3.5；最小=85.0，最大=102），61.3%（n=336）为女性。研究结果显示，65.0%的社区居住的高龄老人使用潜在不适当的药物，中位数为 1 种（最小=0，最大=6）。潜在不适当药物的使用随着用药数量的增加呈线性增加（p=0.001）。潜在不适当药物使用者组的药物中位数明显更高（5 种 vs. 2 种，p=0.001）。利尿剂、质子泵抑制剂和非甾体抗炎药是最常使用的潜在不适当药物。
在土耳其，高龄老人中潜在不适当用药的使用频率很高。根据年龄、性别或地理区域，用药频率没有差异。重要的是要预防应避免使用的潜在不适当药物，并监测应谨慎使用潜在不适当药物的高龄老人群体。
