Soni Nikita, Niranjane Priyanka, Purohit Akanksha
Department of Orthodontics and Dentofacial Orthopaedics, Sharad Pawar Dental College and Hospital, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Neglected Tropical Diseases, Global Health Strategies, Delhi, IND.
Cureus. 2024 Aug 19;16(8):e67202. doi: 10.7759/cureus.67202. eCollection 2024 Aug.
This review aims to investigate the properties of growth factors concerning the morphogenesis and development of nasal cartilage, which is fundamentally important for facial form and appearance. Since cartilage lacks a blood supply, it is more difficult to regenerate, as cartilage tissue obtains sustenance by diffusion. Cytokines are signalling molecules that control chondrocyte metabolism and extracellular matrix formation, which is required for cartilage development, homeostasis, and healing. Some craniofacial illnesses alter the composition of the cartilage and the structural organization of growth factors, allowing for moulding. TGF-β (transforming growth factor-β) encourages chondrocyte differentiation, whereas IGF-1 (insulin-like growth factor-1) stimulates cartilage-forming collagen synthesis and chondrocyte multiplication. We used the scoping review approach to present current research on the role of growth factors in the creation and architecture of nasal cartilage. We generally observed this structure before conducting specific experiments to determine the impact of growth agents on the development of chondrocytes and cartilage. Prominent findings increase our understanding of how growth factors influence the extracellular matrix, cell activities and features, and cartilage growth rate; all are critical for cartilage tissue development and repair. Research into growth factors and their physiological interactions with cartilage may help improve treatment's functional and aesthetic outcomes and our understanding of the origins and consequences of nasal congenital anomalies. This study emphasizes the importance of expanding knowledge and experience, as well as the use of growth factors in clinical practice, to stimulate cartilage development.
本综述旨在研究生长因子与鼻软骨形态发生和发育相关的特性，这对面部形态和外观至关重要。由于软骨缺乏血液供应，再生较为困难，因为软骨组织通过扩散获取营养。细胞因子是控制软骨细胞代谢和细胞外基质形成的信号分子，而细胞外基质的形成是软骨发育、稳态维持和愈合所必需的。一些颅面疾病会改变软骨的组成以及生长因子的结构组织，从而实现塑形。转化生长因子-β（TGF-β）促进软骨细胞分化，而胰岛素样生长因子-1（IGF-1）刺激形成软骨的胶原蛋白合成以及软骨细胞增殖。我们采用范围综述方法来呈现当前关于生长因子在鼻软骨形成和结构中作用的研究。在进行特定实验以确定生长因子对软骨细胞和软骨发育的影响之前，我们通常先观察这种结构。显著的研究结果增进了我们对生长因子如何影响细胞外基质、细胞活动和特性以及软骨生长速率的理解；所有这些对于软骨组织的发育和修复都至关重要。对生长因子及其与软骨的生理相互作用的研究可能有助于改善治疗的功能和美学效果，以及我们对鼻先天性异常的起源和后果的理解。本研究强调了扩展知识和经验以及在临床实践中使用生长因子以刺激软骨发育的重要性。
