Puhlmann Marie-Luise, Jokela Roosa, van Dongen Katja Catharina Wilhelmina, Bui Thi Phuong Nam, van Hangelbroek Roland Willem Jan, Smidt Hauke, de Vos Willem Meindert, Feskens Edith Johanna Maria
Laboratory of Microbiology, Wageningen University & Research, Wageningen, The Netherlands.
Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
Gut Microbiome (Camb). 2022 Apr 28;3:e4. doi: 10.1017/gmb.2022.4. eCollection 2022.
We investigated the impact of dried chicory root in a randomised, placebo-controlled trial with 55 subjects at risk for type 2 diabetes on bowel function, gut microbiota and its products, and glucose homeostasis. The treatment increased stool softness (+1.1 ± 0.3 units; 0.034) and frequency (+0.6 ± 0.2 defecations/day; < 0.001), strongly modulated gut microbiota composition (7 % variation; 0.001), and dramatically increased relative levels (3-4-fold) of and spp., in a dose-dependent, reversible manner. A synthetic community, including selected members of these genera and a strain, generated a butyrogenic trophic chain from the product. Faecal acetate, propionate and butyrate increased by 25.8 % (+13.0 ± 6.3 mmol/kg; = 0.023) as did their fasting circulating levels by 15.7 % (+7.7 ± 3.9 μM; 0.057). In the treatment group the glycaemic coefficient of variation decreased from 21.3 ± 0.94 to 18.3 ± 0.84 % ( 0.004), whereas fasting glucose and HOMA-ir decreased in subjects with low baseline levels (-0.3 ± 0.1 mmol/L fasting glucose; 0.0187; -0.14 ± 0.1 HOMA-ir; 0.045). Dried chicory root intake rapidly and reversibly affects bowel function, benefits butyrogenic trophic chains, and promotes glycaemic control.
我们在一项随机、安慰剂对照试验中，对55名有2型糖尿病风险的受试者研究了菊苣根干品对肠道功能、肠道微生物群及其产物以及葡萄糖稳态的影响。该治疗增加了粪便柔软度（+1.1±0.3单位；P=0.034）和频率（+0.6±0.2次排便/天；P<0.001），强烈调节了肠道微生物群组成（7%的变化；P=0.001），并以剂量依赖性、可逆的方式显著提高了某些菌属的相对水平（3至4倍）。一个合成群落，包括这些菌属的选定成员和一株特定菌株，从该产物产生了一条产丁酸的营养链。粪便中的乙酸盐、丙酸盐和丁酸盐增加了25.8%（+13.0±6.3 mmol/kg；P=0.023），其空腹循环水平也增加了15.7%（+7.7±3.9 μM；P=0.057）。在治疗组中，血糖变异系数从21.3±0.94%降至18.3±0.84%（P=0.004），而在基线水平较低的受试者中，空腹血糖和胰岛素抵抗指数（HOMA-ir）降低（空腹血糖-0.3±0.1 mmol/L；P=0.018；HOMA-ir-0.14±0.1；P=0.045）。摄入菊苣根干品能迅速且可逆地影响肠道功能，有益于产丁酸的营养链，并促进血糖控制。
