Samee Weerasak, Matra Khanit, Lakkham Nattawut, Dongkaew Beelawan, Sumkhum Passakorn, Sangwang Wutthichok, Nupangtha Wasin, Promping Jiraporn
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Srinakharinwirot University, Nakhonnayok, 26120, Thailand.
Department of Electrical Engineering, Faculty of Engineering, Srinakharinwirot University, Nakhonnayok, 26120, Thailand.
Heliyon. 2024 Aug 22;10(17):e36676. doi: 10.1016/j.heliyon.2024.e36676. eCollection 2024 Sep 15.
This study investigates the impact of the Electrical Breakdown in Liquid-phase (EBL) process on alkaloid transformation in (Kratom) leaves, focusing on the conversion of mitragynine (MG) to 7-hydroxy mitragynine (7-OH-MG) by using advanced oxidation processes (AOPs). A novel reactor has been developed to enhance plasma exposure to Kratom leaf powdered solutions during the EBL process. Two distinct electrical voltage characteristics, half-positive and negative half-waves, have been utilized for the EBL, with an output voltage of 4.57 kV at a no-load condition and a frequency of 50 Hz. The experimental findings demonstrate a time-dependent enhancement in the transformation process. The highest yield of 7-OH-MG, reaching 2,485 ± 134 μg/g of dried Kratom leaves weight, has been attained with the EBL processing generated by positive half-wave voltage after 20 min of EBL exposure. Notably, the EBL processing generated by positive half-wave voltage has outperformed the one generated by negative half-wave voltage by a significant factor of 2.01.
本研究调查了液相电击穿（EBL）过程对（ kratom ）叶片中生物碱转化的影响，重点研究了通过使用高级氧化过程（AOPs）将帽柱木碱（MG）转化为7-羟基帽柱木碱（7-OH-MG）。已开发出一种新型反应器，以增强在EBL过程中血浆对 kratom 叶粉末溶液的暴露。EBL采用了两种不同的电压特性，即正半波和负半波，空载条件下输出电压为4.57 kV，频率为50 Hz。实验结果表明，转化过程随时间增强。在EBL暴露20分钟后，由正半波电压产生的EBL处理获得了最高产量的7-OH-MG，达到2485±134μg/g干 kratom 叶重量。值得注意的是，由正半波电压产生的EBL处理比由负半波电压产生的EBL处理性能高出2.01倍。
