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光动力疗法治疗一名患有系统性红斑狼疮的年轻女性患者的尖锐湿疣和宫颈上皮内瘤变I级:病例报告

Photodynamic Therapy for Condyloma Acuminatum and Cervical Intraepithelial Neoplasia Grade I in a Young Female Patient with Systemic Lupus Erythematosus: A Case Report.

作者信息

Zhang Na, Ge Hongping, Chen Xinru, Ye Tianhui, Shi Weikang, Wang Meiyan

机构信息

Department of Dermatology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, People's Republic of China.

出版信息

Clin Cosmet Investig Dermatol. 2024 Sep 14;17:2071-2075. doi: 10.2147/CCID.S479720. eCollection 2024.

DOI:10.2147/CCID.S479720
PMID:39296327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11410032/
Abstract

Condyloma acuminatum (CA), commonly known as anogenital warts, is a prevalent sexually transmitted disease primarily caused by low risk human papillomavirus (HPV) types 6 and 11. This case report outlines the successful use of photodynamic therapy (PDT) to treat extensive condyloma acuminatum in a young female patient with systemic lupus erythematosus (SLE) undergoing immunosuppressive treatment. The patient also had cervical intraepithelial neoplasia grade I. Carbon dioxide laser treatment were initially used to remove some surface warts, followed by PDT, resulting in satisfactory outcomes. After seven sessions, the warty growths were successfully removed. Interdisciplinary collaboration, involving rheumatology, gynecology, and dermatology, facilitated comprehensive management. This case highlights the efficacy and safety of PDT in treating condyloma acuminatum and suggests its potential as an alternative treatment for young SLE patients with similar conditions.

摘要

尖锐湿疣(CA),俗称肛门生殖器疣,是一种常见的性传播疾病,主要由低风险人乳头瘤病毒(HPV)6型和11型引起。本病例报告概述了光动力疗法(PDT)成功用于治疗一名患有系统性红斑狼疮(SLE)并正在接受免疫抑制治疗的年轻女性患者的广泛性尖锐湿疣。该患者还患有一级宫颈上皮内瘤变。最初使用二氧化碳激光治疗去除一些表面疣体,随后进行光动力疗法,取得了满意的效果。经过七次治疗,疣体生长被成功去除。风湿科、妇科和皮肤科的多学科协作促进了综合管理。本病例突出了光动力疗法在治疗尖锐湿疣方面的有效性和安全性,并表明其作为患有类似病症的年轻SLE患者的替代治疗方法的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a56/11410032/b07472bc2c51/CCID-17-2071-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a56/11410032/7a2fc27c23c0/CCID-17-2071-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a56/11410032/b07472bc2c51/CCID-17-2071-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a56/11410032/7a2fc27c23c0/CCID-17-2071-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a56/11410032/b07472bc2c51/CCID-17-2071-g0002.jpg

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Photodynamic Therapy for Condyloma Acuminatum and Cervical Intraepithelial Neoplasia Grade I in a Young Female Patient with Systemic Lupus Erythematosus: A Case Report.光动力疗法治疗一名患有系统性红斑狼疮的年轻女性患者的尖锐湿疣和宫颈上皮内瘤变I级:病例报告
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本文引用的文献

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Evaluation of 5-aminolevulinic acid-mediated photodynamic therapy on cervical low-grade squamous intraepithelial lesions with high-risk HPV infection.评估 5-氨基酮戊酸介导的光动力疗法治疗高危型 HPV 感染的宫颈低级别鳞状上皮内病变。
Photodiagnosis Photodyn Ther. 2022 Jun;38:102807. doi: 10.1016/j.pdpdt.2022.102807. Epub 2022 Mar 11.
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Clinical study of anogenital condyloma acuminata treatment with photodynamic therapy including immunocompromised conditions.光动力疗法治疗包括免疫功能低下在内的肛门生殖器尖锐湿疣的临床研究。
Photodiagnosis Photodyn Ther. 2022 Mar;37:102735. doi: 10.1016/j.pdpdt.2022.102735. Epub 2022 Jan 20.
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Sexually transmitted coinfections in patients with anogenital warts - a retrospective analysis of 196 patients.
性传播合并感染在肛门生殖器疣患者中的回顾性分析-196 例患者分析。
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5-aminolevulinic acid photodynamic therapy for anal canal condyloma acuminatum: A series of 19 cases and literature review.5-氨基酮戊酸光动力疗法治疗肛管尖锐湿疣:19 例系列病例及文献复习。
Photodiagnosis Photodyn Ther. 2018 Sep;23:230-234. doi: 10.1016/j.pdpdt.2018.06.022. Epub 2018 Jul 6.
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Adverse effects of topical photodynamic therapy: a consensus review and approach to management.光动力疗法的不良反应:共识综述及处理方法。
Br J Dermatol. 2019 Apr;180(4):715-729. doi: 10.1111/bjd.17131. Epub 2018 Oct 30.
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Photodynamic therapy - mechanisms, photosensitizers and combinations.光动力疗法——机制、光敏剂及联合治疗。
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Decreased blood levels of B lymphocytes and NK cells in patients with systemic lupus erythematosus (SLE) infected with papillomavirus (HPV).系统性红斑狼疮(SLE)患者感染人乳头瘤病毒(HPV)后,B 淋巴细胞和自然杀伤细胞(NK 细胞)的血液水平下降。
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A randomized clinical comparative study of cryotherapy plus photodynamic therapy vs. cryotherapy in the treatment of multiple condylomata acuminata.一项冷冻治疗联合光动力疗法与冷冻治疗治疗多发性尖锐湿疣的随机临床对照研究。
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