a Department of Dermatology and Venereology, Nanfang Hospital, Southern Medical University , Guangzhou , China.
J Dermatolog Treat. 2019 Nov;30(7):714-717. doi: 10.1080/09546634.2018.1544406. Epub 2018 Dec 11.
Condyloma acuminatum are the most common sexually transmitted diseases worldwide, and they are closely associated with human papillomavirus (HPV) infection. Urethral meatus is one of the places that warts occur. Many treatments for uretheral warts have limitations. In this study, we performed 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) on patients and investigated the effectiveness of reducing HPV viral loads. In our study, 21 patients diagnosed with urethral condyloma acuminatum were included. After 4 h treatment of ALA, patients received PDT. Each patient received HPV test before every PDT cycle. The frequency of PDT was dependent on viral load changes. All patients achieved complete clinical remission after the last session of ALA-PDT. There were significant differences in HPV viral loads between pretherapy and after one or three rounds of PDT treatment. ALA-PDT is a safe and effective method for treatment of condyloma acuminatum in urethra meatus. Dynamic monitoring of HPV viral loads can more objectively demonstrate the effectiveness and guide the treatment of PDT.
尖锐湿疣是全球最常见的性传播疾病之一，与人类乳头瘤病毒（HPV）感染密切相关。尿道外口是发生疣的部位之一。许多治疗尿道疣的方法都存在局限性。在这项研究中，我们对患者进行了 5-氨基酮戊酸-光动力疗法（ALA-PDT），并研究了降低 HPV 病毒载量的效果。
在我们的研究中，纳入了 21 名诊断为尿道尖锐湿疣的患者。ALA 治疗 4 小时后，患者接受 PDT。每位患者在每次 PDT 周期前均接受 HPV 检测。PDT 的频率取决于病毒载量的变化。
所有患者在最后一次 ALA-PDT 后均达到完全临床缓解。在治疗前和治疗 1 或 3 轮 PDT 后，HPV 病毒载量有显著差异。
ALA-PDT 是治疗尿道外口尖锐湿疣的一种安全有效的方法。动态监测 HPV 病毒载量可以更客观地显示疗效，并指导 PDT 的治疗。
