Groux Allison R, Walker Elizabeth S, Shemirani Farnoosh, Lee Jennifer E, Irish Amanda K, Rubenstein Linda M, Snetselaar Linda G, Darling Warren G, Wahls Terry L, Titcomb Tyler J
Department of Internal Medicine, University of Iowa, Iowa City, IA 52340, USA.
Department of Biology, University of Iowa, Iowa City, IA 52340, USA.
Sclerosis. 2024 Sep;2(3):156-165. doi: 10.3390/sclerosis2030011. Epub 2024 Jul 4.
Emerging evidence links dietary interventions to favorable multiple sclerosis (MS) outcomes; however, evidence for the efficacy of dietary interventions on functional disability remains sparse. Data from two 12-week, randomized, controlled pilot trials were pooled to investigate the efficacy of a modified Paleolithic diet (Paleo) on functional disability, as assessed by the MS Functional Composite (MSFC), among people diagnosed with MS. Pooled baseline-referenced MSFC scores were calculated from the nine-hole peg test (NHPT), timed 25-foot walk (T25FW), and Paced Auditory Serial Addition Test (PASAT) Z-scores. There was no significant difference in the mean change in MSFC scores between groups ( = 0.07). In the Paleo group, a significant increase was observed in the MSFC scores ( = 0.03), NHPT ( < 0.001), and PASAT ( = 0.04) Z-scores at 12 weeks, indicating reduced functional disability compared to baseline values. No significant changes were observed within the Control group. Study-specific differences in the MSFC changes between groups were observed. Functional disability was reduced compared to the baseline in the Paleo group, possibly depending on MS type. These results provide preliminary observations on the efficacy of a modified Paleolithic diet for reducing or maintaining functional disability in MS.
新出现的证据表明饮食干预与多发性硬化症（MS）的良好预后相关；然而，饮食干预对功能残疾疗效的证据仍然稀少。来自两项为期12周的随机对照试验的数据被汇总起来，以研究改良的旧石器时代饮食（古饮食法）对已确诊患有MS的人群功能残疾的疗效，功能残疾通过MS功能综合评分（MSFC）进行评估。汇总的以基线为参照的MSFC评分由九孔插板测试（NHPT）、25英尺计时步行测试（T25FW）和听觉序列加法测试（PASAT）的Z评分计算得出。两组之间MSFC评分的平均变化没有显著差异（P = 0.07）。在古饮食法组中，12周时MSFC评分（P = 0.03）、NHPT（P < 0.001）和PASAT（P = 0.04）的Z评分显著增加，表明与基线值相比功能残疾有所减轻。在对照组中未观察到显著变化。观察到两组之间MSFC变化存在特定研究的差异。与基线相比，古饮食法组的功能残疾有所减轻，这可能取决于MS的类型。这些结果为改良的旧石器时代饮食在减轻或维持MS功能残疾方面的疗效提供了初步观察。
