β-丙氨酸可促进激光诱导脉络膜新生血管小鼠模型中的血管生成。
Beta-alanine promotes angiogenesis in laser-induced choroidal neovascularization mice models.
作者信息
Wu Jia-Li, Zhang Min, Sun Xiao-Dong
机构信息
Department of Ophthalmology, Shanghai General Hospital (Shanghai First People's Hospital), Shanghai Jiao Tong University, School of Medicine, Shanghai 200080, China.
National Clinical Research Center for Ophthalmic Diseases, Shanghai 200080, China.
出版信息
Int J Ophthalmol. 2024 Sep 18;17(9):1592-1598. doi: 10.18240/ijo.2024.09.03. eCollection 2024.
AIM
To investigate the effect of β-alanine (BA) on laser-induced choroidal neovascularization (CNV) mice models.
METHODS
Laser-induced CNV mice models were established, and BA was administrated for one week and two weeks in advance, separately. Furthermore, retinal pigment epithelium (RPE)-choroid flat mounts were separated, and immunohistochemical staining was performed. The laser-induced CNV lesion areas were measured and compared. In addition, liver and kidney morphologies were observed to identify potential hepatorenal toxicity.
RESULTS
Enlarged CNV lesion areas were observed in the BA treated group. No significant differences were observed in the liver and kidney sections between groups.
CONCLUSION
BA treatment increase CNV lesion areas, suggesting the detrimental effects of BA as a nutritional supplement in age-related macular degeneration (AMD) population.
目的
研究β-丙氨酸（BA）对激光诱导脉络膜新生血管（CNV）小鼠模型的影响。
方法
建立激光诱导CNV小鼠模型，分别提前一周和两周给予BA。此外，分离视网膜色素上皮（RPE）-脉络膜扁平标本并进行免疫组化染色。测量并比较激光诱导的CNV病变面积。另外，观察肝脏和肾脏形态以确定潜在的肝肾毒性。
结果
在BA治疗组中观察到CNV病变面积增大。各组之间肝脏和肾脏切片未观察到显著差异。
结论
BA治疗会增加CNV病变面积，表明BA作为营养补充剂对年龄相关性黄斑变性（AMD）人群有有害影响。
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