Huang Hai-Yan, Wang Jing, Qin Bo, Tan Yao
Clinical Medical College of Guizhou Medical University, Guiyang 550004, Guizhou Province, China.
Postdoctoral Station of Clinical Medicine, The Third Xiangya Hospital, Central South University, Changsha 410000, Hunan Province, China.
Int J Ophthalmol. 2024 Sep 18;17(9):1723-1730. doi: 10.18240/ijo.2024.09.21. eCollection 2024.
To assess the causal link between 211 gut microbiota (GM) taxa and dry age-related macular degeneration (dAMD) risk.
Mendelian randomization using instrumental factors taken from a genome-wide association study (GWAS) were used. Inverse variance weighted (IVW) analysis and sensitivity analysis were performed on the FinnGen project, which included 5095 cases and 222 590 controls.
The IVW analysis showed substantial genus- and family-level relationships between GM taxa and dAMD risk. Specifically, the family (=0.03), genus (=3.91×10), genus (=6.55×10), and genus (=0.04) were linked to a higher risk of developing dAMD, while the genus (=7.75×10), genus (=0.04) and genus (=0.04) exhibited a protective effect against dAMD. No significant causal relationships were observed at higher taxonomic levels. Additionally, in the reverse IVW analysis, no meaningful causal effects of the 7 GM taxa.
These findings give support for the gut-retina axis participation in dAMD and shed light on putative underlying processes. Investigations on the connection between GM and dAMD have not yet revealed the underlying mechanism.
评估211种肠道微生物群（GM）分类群与干性年龄相关性黄斑变性（dAMD）风险之间的因果关系。
使用来自全基因组关联研究（GWAS）的工具因素进行孟德尔随机化。对芬兰基因组计划进行逆方差加权（IVW）分析和敏感性分析，该计划包括5095例病例和222590例对照。
IVW分析显示GM分类群与dAMD风险之间存在显著的属和科级关系。具体而言，[具体科名1]（=0.03）、[具体属名1]（=3.91×10）、[具体属名2]（=6.55×10）和[具体属名3]（=0.04）与发生dAMD的较高风险相关，而[具体属名4]（=7.75×10）、[具体属名5]（=0.04）和[具体属名6]（=0.04）对dAMD具有保护作用。在较高分类水平上未观察到显著的因果关系。此外，在反向IVW分析中，7种GM分类群没有有意义的因果效应。
这些发现支持肠道 - 视网膜轴参与dAMD，并揭示了潜在的过程。关于GM与dAMD之间联系的研究尚未揭示其潜在机制。
