• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新冠肺炎患者不同疾病严重程度的 miRNA 神经炎症生物标志物。

The miRNA neuroinflammatory biomarkers in COVID-19 patients with different severity of illness.

机构信息

Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran; Department of Pathology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran.

出版信息

Neurologia (Engl Ed). 2023 Jul-Aug;38(6):e41-e51. doi: 10.1016/j.nrleng.2023.05.002.

DOI:10.1016/j.nrleng.2023.05.002
PMID:37344097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10278372/
Abstract

INTRODUCTION

The expression of specific miRNAs and their mRNA targets are changed in infectious disease. The aim of this study was to analyze the expression of pro-neuroinflammatory miRNAs, anti-neuroinflammatory miRNAs, and their mRNA targets in the serum of COVID-19 patients with different grades.

METHODS

COVID-19 patients with different grades were enrolled in this study and the expression of pro-neuroinflammatory miRNAs, anti-neuroinflammatory miRNAs, and their target mRNAs was analyzed by q-PCR.

RESULTS

The relative expression of anti- neuroinflammatory miRNAs (mir-21, mir-124, and mir-146a) was decreased and the relative expression of their target mRNAs (IL-12p53, Stat3, and TRAF6) was increased. Also, the relative expression of pro-neuroinflammatory miRNAs (mir-326, mir-155, and mir-27b) was increased and the relative expression of their target mRNA (PPARS, SOCS1, and CEBPA) was decreased in COVID-19 patients with increase of disease grade. A negative significant correlation was seen between mir-21 and IL-12p53 mRNA, mir-124 and Stat3 mRNA, mir-146a and TRAF6 mRNA, mir-27b and PPARS mRNA, mir-155 and SOCS1 mRNA, and between mir-326 and CEBPA mRNA in COVID-19 patients (P<0.05).

CONCLUSIONS

This study showed that the relative expression of anti- neuroinflammatory miRNAs was decreased and the relative expression of their targeted mRNAs was increased in COVID-19 patients from asymptomatic to critical illness. Also, this study showed that the relative expression of pro-neuroinflammatory miRNAs was increased and the relative expression of their targeted mRNA was decreased in COVID-19 patients from asymptomatic to critical illness.

摘要

简介

特定 miRNA 的表达及其 mRNA 靶标在传染病中发生改变。本研究旨在分析不同严重程度 COVID-19 患者血清中促神经炎症 miRNA、抗神经炎症 miRNA 及其 mRNA 靶标的表达。

方法

本研究纳入了不同严重程度的 COVID-19 患者，并通过 q-PCR 分析了促神经炎症 miRNA、抗神经炎症 miRNA 及其靶 mRNA 的表达。

结果

抗神经炎症 miRNA（mir-21、mir-124 和 mir-146a）的相对表达降低，其靶 mRNA（IL-12p53、Stat3 和 TRAF6）的相对表达增加。此外，随着疾病严重程度的增加，COVID-19 患者中促神经炎症 miRNA（mir-326、mir-155 和 mir-27b）的相对表达增加，其靶 mRNA（PPARS、SOCS1 和 CEBPA）的相对表达减少。在 COVID-19 患者中，mir-21 与 IL-12p53 mRNA、mir-124 与 Stat3 mRNA、mir-146a 与 TRAF6 mRNA、mir-27b 与 PPARS mRNA、mir-155 与 SOCS1 mRNA 以及 mir-326 与 CEBPA mRNA 之间存在显著负相关（P<0.05）。

结论

本研究表明，从无症状到危重症 COVID-19 患者中，抗神经炎症 miRNA 的相对表达降低，其靶 mRNA 的相对表达增加。此外，本研究还表明，从无症状到危重症 COVID-19 患者中，促神经炎症 miRNA 的相对表达增加，其靶 mRNA 的相对表达减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/69748f623db0/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/ead717d3b47b/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/3b5046013110/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/8d6d702e9df5/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/aa034dedfee2/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/72c45063a23b/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/69748f623db0/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/ead717d3b47b/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/3b5046013110/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/8d6d702e9df5/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/aa034dedfee2/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/72c45063a23b/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/287e/10278372/69748f623db0/gr6_lrg.jpg

相似文献

1
The miRNA neuroinflammatory biomarkers in COVID-19 patients with different severity of illness.新冠肺炎患者不同疾病严重程度的 miRNA 神经炎症生物标志物。
Neurologia (Engl Ed). 2023 Jul-Aug;38(6):e41-e51. doi: 10.1016/j.nrleng.2023.05.002.
2
The miRNA neuroinflammatory biomarkers in COVID-19 patients with different severity of illness.新冠肺炎不同病情严重程度患者的微小RNA神经炎症生物标志物
Neurologia. 2023 Jul-Aug;38(6):e41-e51. doi: 10.1016/j.nrl.2021.06.005. Epub 2021 Jul 16.
3
The relative expression of miR-31, miR-29, miR-126, and miR-17 and their mRNA targets in the serum of COVID-19 patients with different grades during hospitalization.COVID-19 患者在院期间不同分级时血清中 miR-31、miR-29、miR-126 和 miR-17 及其 mRNA 靶标的相对表达量。
Eur J Med Res. 2021 Jul 13;26(1):75. doi: 10.1186/s40001-021-00544-4.
4
MicroRNA-146a Ameliorates Inflammation via TRAF6/NF-κB Pathway in Intervertebral Disc Cells.微小RNA-146a通过椎间盘细胞中的TRAF6/NF-κB途径减轻炎症
Med Sci Monit. 2017 Feb 5;23:659-664. doi: 10.12659/msm.898660.
5
Expression and Clinical Significance of miR-146a and Tumor Necrosis Factor Receptor-Associated Factor 6 (TRAF6) in Myasthenia Gravis Patient Serum.miR-146a 和肿瘤坏死因子受体相关因子 6（TRAF6）在重症肌无力患者血清中的表达及临床意义。
Biomed Res Int. 2021 Apr 20;2021:5573469. doi: 10.1155/2021/5573469. eCollection 2021.
6
Regulation of the human placental (pro)renin receptor-prorenin-angiotensin system by microRNAs.miRNAs 对人胎盘（前）肾素受体-原肾素-血管紧张素系统的调节。
Mol Hum Reprod. 2018 Sep 1;24(9):453-464. doi: 10.1093/molehr/gay031.
7
The rs2910164 variant is associated with reduced miR-146a expression but not cytokine levels in patients with type 2 diabetes.rs2910164 变异与 2 型糖尿病患者 miR-146a 表达降低而非细胞因子水平降低相关。
J Endocrinol Invest. 2018 May;41(5):557-566. doi: 10.1007/s40618-017-0766-z. Epub 2017 Oct 22.
8
Identifying microRNA-mRNA regulatory network in colorectal cancer by a combination of expression profile and bioinformatics analysis.通过表达谱和生物信息学分析相结合的方法鉴定结直肠癌中的微小RNA-信使核糖核酸调控网络。
BMC Syst Biol. 2012 Jun 15;6:68. doi: 10.1186/1752-0509-6-68.
9
Dysregulation of miRNA-146a contributes to the development of lupus nephritis via targeting of TRAF6.miRNA - 146a的失调通过靶向TRAF6促进狼疮性肾炎的发展。
Per Med. 2017 Mar;14(2):131-139. doi: 10.2217/pme-2016-0065. Epub 2017 Jan 24.
10
MicroRNA regulation in human CD8+ T cell subsets--cytokine exposure alone drives miR-146a expression.人类CD8 + T细胞亚群中的微小RNA调控——仅细胞因子暴露就能驱动miR-146a的表达。
J Transl Med. 2014 Oct 21;12:292. doi: 10.1186/s12967-014-0292-0.

引用本文的文献

1
Decoding the intricacies: a comprehensive analysis of microRNAs in the pathogenesis, diagnosis, prognosis and therapeutic strategies for COVID-19.解读复杂之处：对新冠病毒在发病机制、诊断、预后及治疗策略方面的微小RNA进行全面分析
Front Med (Lausanne). 2024 Oct 7;11:1430974. doi: 10.3389/fmed.2024.1430974. eCollection 2024.
2
The potential of circulating microRNAs as novel diagnostic biomarkers of COVID-19: a systematic review and meta-analysis.循环 microRNAs 作为 COVID-19 新型诊断生物标志物的潜力：系统评价和荟萃分析。
BMC Infect Dis. 2024 Sep 19;24(1):1011. doi: 10.1186/s12879-024-09915-8.
3
The relationship between microRNAs and COVID-19 complications.

本文引用的文献

1
"Neurological manifestations of COVID-19" - guideline of the German society of neurology.《新型冠状病毒肺炎的神经学表现》——德国神经病学学会指南
Neurol Res Pract. 2020 Dec 2;2:51. doi: 10.1186/s42466-020-00097-7. eCollection 2020.
2
Identification of Novel SARS-CoV-2 Drug Targets by Host MicroRNAs and Transcription Factors Co-regulatory Interaction Network Analysis.通过宿主微小RNA和转录因子共调控相互作用网络分析鉴定新型SARS-CoV-2药物靶点
Front Genet. 2020 Oct 14;11:571274. doi: 10.3389/fgene.2020.571274. eCollection 2020.
3
The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system.
微小RNA与新型冠状病毒肺炎并发症之间的关系。
Noncoding RNA Res. 2024 Aug 22;10:16-24. doi: 10.1016/j.ncrna.2024.08.007. eCollection 2025 Feb.
4
Alteration of circulating ACE2-network related microRNAs in patients with COVID-19.新型冠状病毒肺炎患者循环 ACE2 网络相关 microRNAs 的变化。
Sci Rep. 2024 Jun 12;14(1):13573. doi: 10.1038/s41598-024-58037-3.
5
Role of microRNAs in cognitive decline related to COVID‑19 (Review).微小RNA在与2019冠状病毒病相关的认知衰退中的作用（综述）
Exp Ther Med. 2024 Feb 14;27(4):139. doi: 10.3892/etm.2024.12427. eCollection 2024 Apr.
6
Spinal Cord Injury: From MicroRNAs to Exosomal MicroRNAs.脊髓损伤：从 microRNAs 到外泌体 microRNAs。
Mol Neurobiol. 2024 Aug;61(8):5974-5991. doi: 10.1007/s12035-024-03954-7. Epub 2024 Jan 23.
7
SARS-CoV-2-associated organs failure and inflammation: a focus on the role of cellular and viral microRNAs.SARS-CoV-2 相关的器官衰竭和炎症：关注细胞和病毒 microRNAs 的作用。
Virol J. 2023 Aug 9;20(1):179. doi: 10.1186/s12985-023-02152-6.
8
Saliva microRNA Profile in Children with and without Severe SARS-CoV-2 Infection.唾液 microRNA 谱在伴有和不伴有严重 SARS-CoV-2 感染的儿童中的表现。
Int J Mol Sci. 2023 May 3;24(9):8175. doi: 10.3390/ijms24098175.
9
The role of peroxisome proliferator-activated receptors in the modulation of hyperinflammation induced by SARS-CoV-2 infection: A perspective for COVID-19 therapy.过氧化物酶体增殖物激活受体在调节 SARS-CoV-2 感染引起的过度炎症反应中的作用：COVID-19 治疗的一个新视角。
Front Immunol. 2023 Feb 17;14:1127358. doi: 10.3389/fimmu.2023.1127358. eCollection 2023.
10
Role of the MicroRNAs in the Pathogenic Mechanism of Painful Symptoms in Long COVID: Systematic Review.MicroRNAs 在长新冠疼痛症状发病机制中的作用：系统评价。
Int J Mol Sci. 2023 Feb 10;24(4):3574. doi: 10.3390/ijms24043574.
COVID-19 中的细胞因子风暴：趋化因子/趋化因子受体系统的参与概述。
Cytokine Growth Factor Rev. 2020 Jun;53:25-32. doi: 10.1016/j.cytogfr.2020.05.003. Epub 2020 May 11.
4
Cardiac dysfunction and thrombocytopenia-associated multiple organ failure inflammation phenotype in a severe paediatric case of COVID-19.一名重症儿童COVID-19病例中的心脏功能障碍及血小板减少相关的多器官衰竭炎症表型
Lancet Child Adolesc Health. 2020 Jul;4(7):552-554. doi: 10.1016/S2352-4642(20)30163-2. Epub 2020 May 18.
5
Comorbidities and multi-organ injuries in the treatment of COVID-19.新型冠状病毒肺炎治疗中的合并症与多器官损伤
Lancet. 2020 Mar 21;395(10228):e52. doi: 10.1016/S0140-6736(20)30558-4. Epub 2020 Mar 11.
6
The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak.冠状病毒病（COVID-19）疫情的流行病学和发病机制。
J Autoimmun. 2020 May;109:102433. doi: 10.1016/j.jaut.2020.102433. Epub 2020 Feb 26.
7
The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned?严重急性呼吸综合征（SARS）、中东呼吸综合征（MERS）和新型冠状病毒（COVID-19）疫情，最新和最大的全球健康威胁：我们从中吸取了哪些教训？
Int J Epidemiol. 2020 Jun 1;49(3):717-726. doi: 10.1093/ije/dyaa033.
8
Coronavirus Disease 2019 (COVID-19): A Perspective from China.2019 冠状病毒病（COVID-19）：来自中国的视角。
Radiology. 2020 Aug;296(2):E15-E25. doi: 10.1148/radiol.2020200490. Epub 2020 Feb 21.
9
MicroRNAs in Neuroinflammation: Implications in Disease Pathogenesis, Biomarker Discovery and Therapeutic Applications.神经炎症中的微小RNA：在疾病发病机制、生物标志物发现及治疗应用中的意义
Noncoding RNA. 2019 Apr 24;5(2):35. doi: 10.3390/ncrna5020035.
10
Predicting MicroRNA Mediated Gene Regulation between Human and Viruses.预测人类与病毒之间的微小RNA介导的基因调控
Cells. 2018 Aug 8;7(8):100. doi: 10.3390/cells7080100.