Lebwohl Mark G, Medeiros Rose Anne, Mackey Rachel H, Valdecantos Wendell C, Brodovicz Kimberly G, Lertratanakul Apinya, Strober Bruce
Icahn School of Medicine at Mount Sinai, New York, NY, USA.
CorEvitas, LLC, Waltham, MA, USA.
J Psoriasis Psoriatic Arthritis. 2023 Apr;8(2):56-65. doi: 10.1177/24755303221146990. Epub 2022 Dec 26.
Palmoplantar pustulosis (PPP) is a rare skin disease characterized by episodes of neutrophilic pustules on the palms of the hands and soles of the feet. Current treatments for PPP have limited efficacy, and there is little real-world evidence characterizing the disease burden of PPP in patients.
To describe and compare the clinical characteristics and patient-reported outcomes (PROs) of patients with PPP with those of patients with plaque psoriasis.
This real-world study used data from patients with PPP or plaque psoriasis enrolled in the CorEvitas Psoriasis Registry. Disease characteristics, historical medical data, PROs, and quality-of-life measures were compared between patients with PPP and those with plaque psoriasis. These measures were also compared following patient stratification by body surface area involvement or Psoriasis Area and Severity Index. This study is purely descriptive; no hypothesis testing was performed.
In this data set, patients with PPP (n = 64) reported higher mean overall pain, using the visual analog scale, relative to those with plaque psoriasis (n = 4894). Patients with PPP also reported a greater proportion of work hours missed or affected; greater impairment of work; and greater impairment of daily activity than patients with plaque psoriasis. Similar effects were observed irrespective of patient stratification.
Generally, PPP was associated with worse PROs and a greater impact on quality of life compared with plaque psoriasis. These findings highlight a need to develop effective therapies for PPP to improve disease management.
掌跖脓疱病（PPP）是一种罕见的皮肤病，其特征为手掌和脚底出现嗜中性脓疱。目前PPP的治疗效果有限，而且几乎没有实际证据来描述患者中PPP的疾病负担。
描述并比较PPP患者与斑块状银屑病患者的临床特征及患者报告结局（PROs）。
这项真实世界研究使用了CorEvitas银屑病登记处中PPP患者或斑块状银屑病患者的数据。比较了PPP患者与斑块状银屑病患者之间的疾病特征、既往病史数据、PROs及生活质量指标。在根据体表面积受累情况或银屑病面积和严重程度指数对患者进行分层后，也对这些指标进行了比较。本研究纯属描述性研究；未进行假设检验。
在该数据集中，PPP患者（n = 64）使用视觉模拟量表报告的平均总体疼痛程度高于斑块状银屑病患者（n = 4894）。与斑块状银屑病患者相比，PPP患者报告的误工时间或受影响工作时间的比例更高；工作受损程度更大；日常活动受损程度也更大。无论患者如何分层，均观察到类似的结果。
总体而言，与斑块状银屑病相比，PPP与更差的PROs及对生活质量更大的影响相关。这些发现凸显了开发有效治疗PPP的方法以改善疾病管理的必要性。
