Department of Computer and Simulation Technology, Faculty of Health Service, Naval Medical University, Shanghai, China.
China-Japan Union Hospital of Jilin University, Changchun, China.
Front Endocrinol (Lausanne). 2024 Sep 4;15:1445787. doi: 10.3389/fendo.2024.1445787. eCollection 2024.
This study presented the new Life's Essential 8 (LE8) framework for examining cardiovascular health (CVH) to analyze the potential relationship between the latter and hyperuricemia (HUA) in the U.S. population.
Data on individuals aged at least 20 years were collected from the National Health and Nutrition Examination Survey (NHANES) 2009-2020. Smoothed curve fitting and multivariate logistic regression analyses were then performed on a sample of 25,681 adults to explore the association between LE8 and HUA. A sensitivity analysis was conducted to examine the robustness of the research findings.
The study found a strong negative association between LE8 and HUA, with an odds ratio (OR) of 0.71 and a 95% confidence interval (CI) from 0.69 to 0.73 after adjusting for multiple confounding factors. The sensitivity analysis further validated the robustness of this association. This analysis consistently showed negative associations across different genders, ages, races, and education levels ( < 0.05), but there were no significant relationships with marital status. The association between uric acid levels and LE8 displayed an inverted L-shaped curve, with an inflection point around 41.43.
The findings indicate a strong negative relationship between LE8 and HUA among the U.S. population, suggesting that higher scores on the LE8, which assesses CVH, were associated with reduced uric acid levels. The consistent negative association underscores the LE8 framework's potential as a valuable tool for understanding and managing HUA in CVH.
本研究提出了新的生命基本 8（LE8）框架来评估心血管健康（CVH），以分析后者与美国人群中超尿酸血症（HUA）之间的潜在关系。
从 2009-2020 年国家健康和营养检查调查（NHANES）中收集了至少 20 岁个体的数据。然后对 25681 名成年人的样本进行了平滑曲线拟合和多变量逻辑回归分析，以探讨 LE8 与 HUA 之间的关联。进行敏感性分析以检查研究结果的稳健性。
研究发现 LE8 与 HUA 之间存在很强的负相关关系，在调整了多个混杂因素后，优势比（OR）为 0.71，95%置信区间（CI）为 0.69-0.73。敏感性分析进一步验证了这种关联的稳健性。该分析一致表明，在不同性别、年龄、种族和教育水平（<0.05）下，均存在负相关关系，但与婚姻状况无关。尿酸水平与 LE8 之间的关系呈倒 L 形曲线，拐点约为 41.43。
研究结果表明，LE8 与美国人群中超尿酸血症之间存在很强的负相关关系，这表明 LE8 评估 CVH 的评分越高，尿酸水平越低。这种一致的负相关关系突显了 LE8 框架作为理解和管理 CVH 中 HUA 的有价值工具的潜力。
