Health Management Center, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Department of Pharmacy, Second Affiliated Hospital of Naval Medical University, Shanghai, China.
Front Endocrinol (Lausanne). 2024 Sep 4;15:1451908. doi: 10.3389/fendo.2024.1451908. eCollection 2024.
Alzheimer's Disease (AD) is increasingly recognized as being associated with metabolic disorders, including Metabolic Associated Steatotic Liver Disease (MASLD). This study aimed to assess the relative risk of AD in individuals with MASLD.
In this retrospective cohort study, we analyzed data from individuals aged over 65 who underwent health check-ups between January 2018 and June 2023. MASLD was diagnosed based on ultrasound findings and cardiometabolic criteria. AD incidence was identified using ICD-10 codes and self-reports. Poisson regression models estimated the relative risk of AD in relation to MASLD, adjusting for age, BMI, sex, SBP, HbA1c, HDL-c, triglycerides, hs-CRP, GGT, and estimated GFR.
The study included 4,582 MASLD patients and 6,318 controls. MASLD patients showed a higher incidence of AD (127 cases) compared to controls (61 cases). The fully adjusted Poisson regression model indicated an increased AD risk in MASLD patients [RR: 2.80 (95% CI: 1.79-4.38)].
Our findings suggested MASLD as an independent risk factor for AD, underlining the role of metabolic dysfunctions in AD pathogenesis. The study emphasized the need for comprehensive metabolic health management in AD prevention strategies, particularly among high-risk groups.
阿尔茨海默病（AD）越来越被认为与代谢紊乱有关，包括代谢相关脂肪性肝病（MASLD）。本研究旨在评估 MASLD 个体患 AD 的相对风险。
在这项回顾性队列研究中，我们分析了 2018 年 1 月至 2023 年 6 月期间接受健康检查的年龄在 65 岁以上个体的数据。根据超声检查结果和心脏代谢标准诊断 MASLD。使用 ICD-10 代码和自我报告确定 AD 发病率。泊松回归模型估计了 MASLD 与 AD 之间的相对风险，调整了年龄、BMI、性别、SBP、HbA1c、HDL-c、甘油三酯、hs-CRP、GGT 和估计的肾小球滤过率。
该研究纳入了 4582 例 MASLD 患者和 6318 例对照。与对照组（61 例）相比，MASLD 患者的 AD 发病率更高（127 例）。完全调整的泊松回归模型表明，MASLD 患者的 AD 风险增加[RR：2.80（95%CI：1.79-4.38）]。
我们的研究结果表明，MASLD 是 AD 的独立危险因素，突出了代谢功能障碍在 AD 发病机制中的作用。该研究强调了在 AD 预防策略中需要对代谢健康进行全面管理，特别是在高风险人群中。
