Department of Obstetrics and Gynecology, Lishui Hospital of Traditional Chinese Medicine, Lishui, Zhejiang, China.
Department of Obstetrics and Gynecology, Affiliated Hospital of Jining Medical College, Jining, Shandong, China.
Front Endocrinol (Lausanne). 2024 Sep 4;15:1424033. doi: 10.3389/fendo.2024.1424033. eCollection 2024.
Infertility is a fertility disorder caused by various factors, with lipid metabolism playing a crucial role in its development. The cardiometabolic index (CMI), which combines blood lipids (TG/HDL-C) and obesity-related parameters (WHtR), is a new quantitative indicator. This study used NHANES data to investigate the relationship between CMI and the incidence of infertility.
We utilized data from women who took part in the National Health and Nutrition Examination Survey (NHANES) from 2015 to March 2020 to calculate the CMI index. Subsequently, we used multivariate logistic regression, smooth curve fitting, and subgroup analysis to investigate the relationship between the CMI index and infertility.
The logistic regression model revealed a significant positive correlation between the CMI index and infertility, even after adjusting for all confounding variables (OR=3.23, 95%CI: 1.55-6.73, p=0.0017). This association remained consistent across all subgroups (p>0.05 for all interactions). Smooth curve fitting demonstrated a positive nonlinear relationship between CMI and infertility. However, the CMI index had limited diagnostic power for infertility (AUC=0.60, 95%CI: 0.56-0.65). However, the CMI-BMI index combined with BMI had good predictive performance (AUC=0.722, 95%CI: 0.676-0.767).
The CMI index shows a positive correlation with infertility, but its diagnostic value is restricted. The combination with BMI has good diagnostic value. Further investigation is required to determine the effectiveness of the CMI index as an early indicator of infertility.
不孕症是一种由多种因素引起的生育障碍，脂代谢在其发病过程中起着关键作用。联合血脂（TG/HDL-C）和肥胖相关参数（WHtR）的心脏代谢指数（CMI）是一种新的定量指标。本研究使用 NHANES 数据调查了 CMI 与不孕症发病之间的关系。
我们利用参加 2015 年至 2020 年 3 月国家健康和营养检查调查（NHANES）的女性的数据来计算 CMI 指数。随后，我们使用多变量逻辑回归、平滑曲线拟合和亚组分析来研究 CMI 指数与不孕症之间的关系。
逻辑回归模型显示，CMI 指数与不孕症之间存在显著的正相关关系，即使在调整了所有混杂变量后也是如此（OR=3.23，95%CI：1.55-6.73，p=0.0017）。这种关联在所有亚组中均保持一致（所有交互作用的 p 值均>0.05）。平滑曲线拟合显示 CMI 与不孕症之间存在正非线性关系。然而，CMI 指数对不孕症的诊断能力有限（AUC=0.60，95%CI：0.56-0.65）。然而，CMI-BMI 指数与 BMI 结合具有良好的预测性能（AUC=0.722，95%CI：0.676-0.767）。
CMI 指数与不孕症呈正相关，但诊断价值有限。与 BMI 结合具有良好的诊断价值。需要进一步研究以确定 CMI 指数作为不孕症早期指标的有效性。
