Fu Yu, Peng Mengling, Cai He, Li Bing, Zhang Yaoting, Zheng Yang
Department of Cardiovascular Diseases, The First Hospital of Jilin University, Changchun, China.
Front Nutr. 2025 Apr 23;12:1587240. doi: 10.3389/fnut.2025.1587240. eCollection 2025.
The relationship between the gut microbiota and infertility has garnered increasing attention. However, the associations between dietary index for gut microbiota (DI-GM), an indicator of microbial diversity, and infertility remain insufficiently explored.
We analyzed data from 3,058 participants in the NHANES 2013-2020 cycles, employing weighted generalized linear models and smooth curve analyses to examine their associations. Mediation analysis was conducted to assess the role of body mass index (BMI).
After adjusting for confounding factors, a higher DI-GM score was significantly associated with a lower prevalence of infertility (OR = 0.89, 95% CI = 0.81-0.98, = 0.029). Compared with individuals with a DI-GM score of 0-3, those with a score ≥6 presented a significantly lower prevalence of infertility (OR = 0.64, 95% CI = 0.43-0.96, = 0.039). BMI mediated 5.98% of the association between DI-GM and infertility.
A higher DI-GM score is associated with a lower prevalence of infertility. Future studies should employ longitudinal designs to validate these findings.
肠道微生物群与不孕症之间的关系日益受到关注。然而，作为微生物多样性指标的肠道微生物群饮食指数（DI-GM）与不孕症之间的关联仍未得到充分探索。
我们分析了2013 - 2020年美国国家健康与营养检查调查（NHANES）各周期中3058名参与者的数据，采用加权广义线性模型和平滑曲线分析来检验它们之间的关联。进行中介分析以评估体重指数（BMI）的作用。
在调整混杂因素后，较高的DI-GM评分与较低的不孕症患病率显著相关（OR = 0.89，95%CI = 0.81 - 0.98，P = 0.029）。与DI-GM评分为0 - 3的个体相比，评分≥6的个体不孕症患病率显著较低（OR = 0.64，95%CI = 0.43 - 0.96，P = 0.039）。BMI介导了DI-GM与不孕症之间5.98%的关联。
较高的DI-GM评分与较低的不孕症患病率相关。未来的研究应采用纵向设计来验证这些发现。
