Cheng Lulu, Wu Qinggang, Wang Siyu
College of Acupuncture-Moxibustion and Tuina, Anhui University of Chinese Medicine, Hefei, 230012, China.
Graduate School, Wuhan Sports University, Wuhan, 430079, China.
Hormones (Athens). 2024 Sep;23(3):477-486. doi: 10.1007/s42000-024-00572-9. Epub 2024 Jun 11.
The cardiometabolic index (CMI) is a new type of obesity index that is based on a combination of lipid levels and abdominal obesity indicators. It is closely correlated with the occurrence of diabetes mellitus, atherosclerosis, hypertension, and other diseases, thus playing an important role in the screening of metabolic diseases. This is coupled with hepatic steatosis and fibrosis which are characterized by excessive liver fat deposition. The aim of this study was to investigate the possible association between CMI and hepatic steatosis and liver fibrosis.
A cross-sectional investigation was conducted using the 2017-2020 National Health and Nutrition Examination Survey (NHANES) dataset to probe the relationship between CMI and hepatic steatosis and liver fibrosis, while multiple linear regression models were used to test the linear association between CMI and controlled attenuation parameter (CAP) and liver stiffness measurement (LSM). Smooth-fit curves and threshold effects analysis were used to describe the nonlinear relationships. Subgroup analyses were performed according to gender, age, body mass index (BMI), hypertension, diabetes, cardiovascular disease, and smoking status.
A total of 3084 adults aged 18-80 years were included in this analysis, and after controlling for a variety of variables, there was a significant positive correlation between CMI and CAP [20.38 (16.27,24.49)]. When subgroups were analyzed, this positive correlation was found to be stronger in the female population than in the male (P for interaction = 0.0303). Furthermore, the association between CMI and CAP was nonlinear. Using multiple regression analysis, it was shown that the linear relationship between CMI and liver fibrosis was not significant [-0.09 (-0.47,0.29)].
The findings suggest that elevated CMI levels are associated with hepatic steatosis, but that CMI is not linked to liver fibrosis. Larger prospective investigations are needed to confirm our findings.
心脏代谢指数（CMI）是一种新型肥胖指数，基于血脂水平和腹部肥胖指标综合得出。它与糖尿病、动脉粥样硬化、高血压及其他疾病的发生密切相关，因此在代谢疾病筛查中发挥重要作用。这与以肝脏脂肪过度沉积为特征的肝脂肪变性和肝纤维化相关。本研究旨在探讨CMI与肝脂肪变性及肝纤维化之间可能存在的关联。
利用2017 - 2020年美国国家健康与营养检查调查（NHANES）数据集进行横断面调查，以探究CMI与肝脂肪变性及肝纤维化之间的关系，同时使用多元线性回归模型检验CMI与受控衰减参数（CAP）及肝脏硬度测量值（LSM）之间的线性关联。采用平滑拟合曲线和阈值效应分析来描述非线性关系。根据性别、年龄、体重指数（BMI）、高血压、糖尿病、心血管疾病及吸烟状况进行亚组分析。
本分析共纳入3084名18 - 80岁的成年人，在控制各种变量后，CMI与CAP之间存在显著正相关[20.38（16.27，24.49）]。在进行亚组分析时，发现这种正相关在女性人群中比男性更强（交互作用P = 0.0303）。此外，CMI与CAP之间的关联是非线性的。通过多元回归分析表明，CMI与肝纤维化之间的线性关系不显著[-0.09（-0.47，0.29）]。
研究结果表明，CMI水平升高与肝脂肪变性相关，但CMI与肝纤维化无关。需要更大规模的前瞻性研究来证实我们的发现。
