1958年至1982年在瑞典分离出的单核细胞增生李斯特菌菌株的抗菌药敏性。
Antimicrobial susceptibilities of Listeria monocytogenes strains isolated from 1958 to 1982 in Sweden.
作者信息
Larsson S, Walder M H, Cronberg S N, Forsgren A B, Moestrup T
出版信息
Antimicrob Agents Chemother. 1985 Jul;28(1):12-4. doi: 10.1128/AAC.28.1.12.
Abstract
Antibiotic susceptibility was studied in 175 clinical isolates of Listeria monocytogenes. There were no major changes in the susceptibility of strains between 1958 and 1982. Benzylpenicillin and ampicillin had MICs for 90% of the strains (MIC90) of 0.5 micrograms/ml. Gentamicin also had good activity against L. monocytogenes, with an MIC90 of 1.0 microgram/ml. All the new beta-lactamase-stable cephalosporins tested had relatively poor activity against L. monocytogenes. Of the bacteriostatic antibiotics, trimethoprim had by far the lowest MIC90 (0.06 microgram/ml), and in combination with sulfamethoxazole (co-trimoxazole), it had an MIC90 of 0.5 microgram/ml. Both erythromycin and doxycycline had low MIC90s (0.25 microgram/ml).
摘要
对175株单核细胞增生李斯特菌临床分离株进行了抗生素敏感性研究。1958年至1982年间，菌株的敏感性没有重大变化。苄青霉素和氨苄西林对90%的菌株的最低抑菌浓度（MIC90）为0.5微克/毫升。庆大霉素对单核细胞增生李斯特菌也有良好活性，MIC90为1.0微克/毫升。所有测试的新型β-内酰胺酶稳定头孢菌素对单核细胞增生李斯特菌的活性相对较差。在抑菌抗生素中，甲氧苄啶的MIC90最低（0.06微克/毫升），与磺胺甲恶唑（复方新诺明）联合使用时，MIC90为0.5微克/毫升。红霉素和强力霉素的MIC90均较低（0.25微克/毫升）。
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