Suppr超能文献

单核细胞增生李斯特菌临床分离株的抗生素敏感性及协同作用

Antibiotic susceptibility and synergy of clinical isolates of Listeria monocytogenes.

作者信息

Tuazon C U, Shamsuddin D, Miller H

出版信息

Antimicrob Agents Chemother. 1982 Mar;21(3):525-7. doi: 10.1128/AAC.21.3.525.

Abstract

Antibiotic susceptibility and synergy were studied in 12 clinical isolates of Listeria monocytogenes from patients with meningitis and septicemia. Rifampin and trimethoprim-sulfamethoxazole (TMP-SMX) were the most potent single drugs tested. Approximately 80% of the strains demonstrated full synergistic bactericidal activity with rifampin in combination with penicillin or ampicillin. Clinical experience dictates that ampicillin or penicillin should remain the antibiotic of choice in the treatment of severe infections, such as meningitis caused by L. monocytogenes. Where the use of penicillin is contraindicated (e.g., allergy or failure to respond), use of TMP-SMX might be considered. Further in vitro and vivo studies are needed before therapy with rifampin or TMP-SMX in combination with penicillin or ampicillin can be recommended.

摘要

对12株从患有脑膜炎和败血症患者中分离出的单核细胞增生李斯特菌临床菌株进行了抗生素敏感性和协同作用研究。利福平以及甲氧苄啶-磺胺甲恶唑(TMP-SMX)是所测试的最有效的单一药物。大约80%的菌株在利福平与青霉素或氨苄西林联合使用时表现出完全的协同杀菌活性。临床经验表明,氨苄西林或青霉素仍应是治疗严重感染(如由单核细胞增生李斯特菌引起的脑膜炎)的首选抗生素。在青霉素使用禁忌的情况下(如过敏或无反应),可考虑使用TMP-SMX。在推荐利福平或TMP-SMX与青霉素或氨苄西林联合治疗之前,还需要进一步的体外和体内研究。

相似文献

4
Antibiotic susceptibility of Listeria monocytogenes in Argentina.阿根廷单核细胞增生李斯特菌的抗生素敏感性
Enferm Infecc Microbiol Clin. 2016 Feb;34(2):91-5. doi: 10.1016/j.eimc.2015.03.007. Epub 2015 May 12.
10
Susceptibility testing of Listeria monocytogenes. A reassessment of bactericidal activity as a predictor for clinical outcome.
Diagn Microbiol Infect Dis. 1991 Jul-Aug;14(4):311-7. doi: 10.1016/0732-8893(91)90022-8.

引用本文的文献

5
Management of listeriosis.李斯特菌病的管理
Clin Microbiol Rev. 1997 Apr;10(2):345-57. doi: 10.1128/CMR.10.2.345.

本文引用的文献

3
Listeriosis in humans: an evaluation.人类李斯特菌病:一项评估。
J Infect Dis. 1971 Mar;123(3):247-50. doi: 10.1093/infdis/123.3.247.
5
Cerebrospinal fluid concentrations of rifampin in meningeal tuberculosis.
Am Rev Respir Dis. 1972 Sep;106(3):432-7. doi: 10.1164/arrd.1972.106.3.432.
7
Letter: Trimethoprim-sulfamethoxazole and brain abscess.
Ann Intern Med. 1975 Jun;82(6):812-3. doi: 10.7326/0003-4819-82-6-812.
8
Rifampin for CSF shunt infections caused by coagulase-negative staphylococci.
J Pediatr. 1979 Aug;95(2):317-9. doi: 10.1016/s0022-3476(79)80682-4.
9
Rifampicin against experimental listeriosis in the mouse.
Chemotherapy. 1978;24(2):104-11. doi: 10.1159/000237768.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验