Tuazon C U, Shamsuddin D, Miller H
Antimicrob Agents Chemother. 1982 Mar;21(3):525-7. doi: 10.1128/AAC.21.3.525.
Antibiotic susceptibility and synergy were studied in 12 clinical isolates of Listeria monocytogenes from patients with meningitis and septicemia. Rifampin and trimethoprim-sulfamethoxazole (TMP-SMX) were the most potent single drugs tested. Approximately 80% of the strains demonstrated full synergistic bactericidal activity with rifampin in combination with penicillin or ampicillin. Clinical experience dictates that ampicillin or penicillin should remain the antibiotic of choice in the treatment of severe infections, such as meningitis caused by L. monocytogenes. Where the use of penicillin is contraindicated (e.g., allergy or failure to respond), use of TMP-SMX might be considered. Further in vitro and vivo studies are needed before therapy with rifampin or TMP-SMX in combination with penicillin or ampicillin can be recommended.
对12株从患有脑膜炎和败血症患者中分离出的单核细胞增生李斯特菌临床菌株进行了抗生素敏感性和协同作用研究。利福平以及甲氧苄啶-磺胺甲恶唑(TMP-SMX)是所测试的最有效的单一药物。大约80%的菌株在利福平与青霉素或氨苄西林联合使用时表现出完全的协同杀菌活性。临床经验表明,氨苄西林或青霉素仍应是治疗严重感染(如由单核细胞增生李斯特菌引起的脑膜炎)的首选抗生素。在青霉素使用禁忌的情况下(如过敏或无反应),可考虑使用TMP-SMX。在推荐利福平或TMP-SMX与青霉素或氨苄西林联合治疗之前,还需要进一步的体外和体内研究。