Wang Xiaowu, Li Tuantuan, Liu Yan, Zhu Yilang, Chen Lichang, Gao Yong
Department of Clinical Laboratory, The Second People's Hospital of Fuyang City, Fuyang, Anhui, People's Republic of China.
Department of Clinical Laboratory, Fuyang Infection Disease Clinical College of Anhui Medical University, Fuyang, Anhui, People's Republic of China.
Infect Drug Resist. 2024 Sep 14;17:3989-4000. doi: 10.2147/IDR.S475652. eCollection 2024.
We retrospectively review consecutive patients with nontuberculous mycobacterium (NTM) pulmonary disease reported from a designated hospital for infectious diseases in the Fuyang district of China to determine the clinical characteristics of these patients.
This research enrolled 234 patients with NTM pulmonary disease between January 2018 and May 2023 in the Fuyang district of China. Data were collected from the electronic medical records. The NTM strain composition and clinical characteristics of NTM pulmonary disease were retrospectively analyzed.
73 (31.20%) patients had previous tuberculosis (TB) or TB exposure history and bronchiectasis. Mixed NTM infection accounted for 12.39%. strain was detected in 132 patients (49.62%). Women were found to be more affected by infection, and men by infection. (34.21%) and (33.33%) strains were most common in people with previous TB or TB exposure history. Among respiratory tract-related diseases, patients with bronchiectasis had the highest isolation rate of (55.36%). Women were susceptible to bronchiectasis ( <0.01). The median of mononuclear-to-lymphocyte ratio (MLR) was higher in men than in women (P < 0.01). The serum albumin (ALB) level was lower in patients with TB or TB exposure history than in those without TB history ( = 0.034). The prognostic nutritional index (PNI) was lower in patients with TB or TB exposure history than in those without tuberculosis history ( = 0.021). Patients with NTM lung disease were poorly treated.
Clinical symptoms of the disease were not species-specific. and strains were predominant in the Fuyang district of China. Previous TB or TB exposure history immensely enhanced the risk of NTM disease.
我们回顾性分析了中国富阳区一家指定传染病医院报告的非结核分枝杆菌（NTM）肺病连续病例，以确定这些患者的临床特征。
本研究纳入了2018年1月至2023年5月期间在中国富阳区的234例NTM肺病患者。数据从电子病历中收集。对NTM肺病的NTM菌株组成和临床特征进行了回顾性分析。
73例（31.20%）患者有既往结核病（TB）或TB暴露史及支气管扩张症。混合NTM感染占12.39%。132例患者（49.62%）检测到 菌株。发现女性受 感染影响更大，男性受 感染影响更大。在有既往TB或TB暴露史的人群中， （34.21%）和 （33.33%）菌株最为常见。在呼吸道相关疾病中，支气管扩张症患者的 分离率最高（55.36%）。女性易患支气管扩张症（P<0.01）。男性单核细胞与淋巴细胞比值（MLR）的中位数高于女性（P<0.01）。有TB或TB暴露史的患者血清白蛋白（ALB）水平低于无TB病史的患者（P = 0.034）。有TB或TB暴露史的患者预后营养指数（PNI）低于无结核病病史的患者（P = 0.021）。NTM肺病患者治疗效果不佳。
该疾病的临床症状无物种特异性。在中国富阳区， 和 菌株占主导。既往TB或TB暴露史极大地增加了NTM病的风险。
