Department of Infectious Diseases, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Department of Clinical Pathology, Instituto Português de Oncologia de Coimbra, Coimbra, Portugal.
Epidemiol Infect. 2022 Dec 12;151:e8. doi: 10.1017/S0950268822000899.
A cross-sectional and retrospective study of patients with spp. in a Portuguese tertiary hospital, in 2009 and 2019, was performed to understand better the rise in isolations of nontuberculous mycobacteria (NTM). The number of patients with positive samples for spp. grew from 56 in 2009 to 83 in 2019. The proportion of NTM rose from 39.3% to 49.4% ( = 0.240), with being more frequent in 2009 and in 2019, and decreased from 60.7% to 50.6%. Higher age was associated with NTM in both years, and pulmonary disease and immunosuppression were associated with NTM in 2019 ( < 0.05), with weak to moderate correlation ( = 0.231-0.343). The overall rise of NTM, allied to their known capacity to resist antimicrobial therapy, alerts clinicians to the importance of recognising potential risk factors for infection and improving future prevention strategies.
本研究对葡萄牙一家三级医院 2009 年和 2019 年的 spp. 患者进行了横断面和回顾性研究，旨在更好地了解非结核分枝杆菌（NTM）分离株上升的原因。2009 年阳性样本中 spp. 患者数量为 56 例，2019 年增加至 83 例。NTM 的比例从 2009 年的 39.3%上升至 2019 年的 49.4%（=0.240），2009 年 更为常见，而 2019 年 更为常见，从 60.7%下降至 50.6%。在这两年中，年龄较高与 NTM 有关，而肺部疾病和免疫抑制与 2019 年的 NTM 有关（<0.05），具有弱至中度相关性（=0.231-0.343）。NTM 的整体上升，以及它们已知的抗微生物治疗能力，提醒临床医生注意识别感染的潜在危险因素，并改进未来的预防策略。
