Department of Biochemistry, Indian Academy Degree College - Autonomous, Bangalore, India.
Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Deoghar, India.
J Food Biochem. 2022 Sep;46(9):e14230. doi: 10.1111/jfbc.14230. Epub 2022 May 11.
Plant-derived flavonoids are reported to function as potential anti-cancer agents against different types of cancer. Baicalein (BE) is an important flavonoid found in the roots of Scutellaria baicalensis that is popularly used in Chinese medicine as an ingredient in herbal tea preparations to promote wellness. BE has been studied for its several biological effects including antioxidant, anti-inflammatory, anti-hepatotoxic, antiviral, and anti-tumor properties. BE has now been discovered to be an effective agent against lung neoplasm. The molecular factors supporting baicalein's anti-cancer activity against lung cancer and its value to human health are discussed in this article. This would help in identifying BE as a promising competent drug against lung carcinoma. PRACTICAL APPLICATIONS: Baicalein is a flavonoid obtained from the roots of Scutellaria baicalensis. It has been widely used as an antioxidant, anti-inflam5matory, anti-hepatotoxic, antiviral, and anti-cancer agent. Lung cancer is one of the most common malignancies in the world with a high fatality rate. Several studies have found that Baicalein is an important candidate for treating lung cancer. Its mechanism of action includes regulation of cell proliferation, metastasis, apoptosis, autophagy, and so on. Baicalein could be used as a novel anti-cancer drug for the treatment of lung carcinoma.
植物来源的类黄酮被报道具有作为针对不同类型癌症的潜在抗癌剂的功能。黄芩素 (BE) 是黄芩根中重要的黄酮类化合物，在中国传统医学中被广泛用作草药茶制剂的成分，以促进健康。BE 因其多种生物学效应而受到研究，包括抗氧化、抗炎、抗肝毒性、抗病毒和抗肿瘤特性。BE 现已被发现是一种有效的抗肺癌药物。本文讨论了支持黄芩素对抗肺癌的抗癌活性及其对人类健康价值的分子因素。这有助于将 BE 鉴定为一种有前途的治疗肺癌的有效药物。实际应用：黄芩素是从黄芩的根中提取的一种黄酮类化合物。它已被广泛用作抗氧化剂、抗炎剂、抗肝毒性、抗病毒剂和抗癌剂。肺癌是世界上最常见的恶性肿瘤之一，死亡率很高。多项研究发现，黄芩素是治疗肺癌的重要候选药物。其作用机制包括调节细胞增殖、转移、凋亡、自噬等。黄芩素可作为一种新型的抗癌药物，用于治疗肺癌。
