Lisboa Fabiola Socorro Silva, Benevento Enzo Martins, Kaneko Luisa Oliveira, Bertolucci Vanessa, Rosini Silva Álex Ap, Sardim André Cabral, Ruiz Valter Ferreira, Dos Reis Ivan Gustavo Masseli, Porcari Andreia M, Messias Leonardo Henrique Dalcheco
Research Group on Technology Applied to Exercise Physiology-GTAFE, Health Sciences Postgraduate Program, São Francisco University, Bragança Paulista, Brazil.
Research Group on Musculoskeletal Rehabilitation, São Francisco University, Bragança Paulista, Brazil.
Front Cell Dev Biol. 2024 Sep 4;12:1454084. doi: 10.3389/fcell.2024.1454084. eCollection 2024.
Obesity aligned with quadriceps muscle weakness contributes to the high incidence of knee osteoarthritis (KOA), which is prevalent in women. Although molecular signatures of KOA have been suggested, the association between biopsychosocial responses and the plasma metabolomic profile in overweight/ obese women with KOA remains in its early stages of investigation. This study aims to associate the plasma metabolome with biopsychosocial parameters of overweight/obese women diagnosed with KOA.
Twenty-eight overweight/obese women (Control-n = 14; KOA-n = 14) underwent two visits to the laboratory. Functional tests and questionnaires assessing biopsychosocial parameters were administered during the first visit. After 48 h, the participants returned to the laboratory for blood collection. Specific to the KOA condition, the Numerical Pain Rating Scale (NPRS), Tampa Scale for Kinesiophobia (TSK), and Knee injury and Osteoarthritis Outcome Score (KOOS) were applied.
Thirteen molecules were different between groups, and four correlated with KOA's biopsychosocial parameters. DG 22:4-2OH and gamma-Glutamylvaline were inversely associated with KOSS leisure and TSK score, respectively. LysoPE 18:0 and LysoPE 20:5 were positively associated with KOSS symptoms and TSK score, respectively.
While the correlations of LysoPE 18:0 and gamma-Glutamylvaline are supported by existing literature, this is not the case for DG 22:4-2OH and LysoPE 20:5. Further studies are recommended to better elucidate these correlations before dismissing their potential involvement in the biopsychosocial factors of the disease.
肥胖与股四头肌无力共同导致膝关节骨关节炎（KOA）的高发病率，该病在女性中尤为普遍。尽管已有研究表明KOA存在分子特征，但超重/肥胖KOA女性的生物心理社会反应与血浆代谢组学特征之间的关联仍处于研究初期。本研究旨在将超重/肥胖KOA女性的血浆代谢组与生物心理社会参数相关联。
28名超重/肥胖女性（对照组n = 14；KOA组n = 14）到实验室进行了两次访视。首次访视时进行了评估生物心理社会参数的功能测试和问卷调查。48小时后，参与者返回实验室进行血液采集。针对KOA情况，应用了数字疼痛评分量表（NPRS）、坦帕运动恐惧量表（TSK）和膝关节损伤与骨关节炎转归评分（KOOS）。
两组之间有13种分子存在差异，其中4种与KOA的生物心理社会参数相关。DG 22:4 - 2OH和γ - 谷氨酰缬氨酸分别与KOOS休闲评分和TSK评分呈负相关。溶血磷脂酰乙醇胺18:0（LysoPE 18:0）和溶血磷脂酰乙醇胺20:5（LysoPE 20:5）分别与KOOS症状评分和TSK评分呈正相关。
虽然现有文献支持LysoPE 18:0和γ - 谷氨酰缬氨酸之间的相关性，但DG 22:4 - 2OH和LysoPE 20:5并非如此。在排除它们可能参与该疾病生物心理社会因素的潜在作用之前，建议进一步研究以更好地阐明这些相关性。
