College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.
Department of Materials Science and Engineering, Research Institute of Advanced Materials, Institute of Engineering Research, Bio-MAX Institute, Soft Foundry Institute, Seoul National University, Seoul, Republic of Korea.
Exp Mol Med. 2023 Sep;55(9):1955-1973. doi: 10.1038/s12276-023-01071-4. Epub 2023 Sep 1.
Adipose tissue is a dynamic and metabolically active organ that plays a crucial role in energy homeostasis and endocrine function. Recent advancements in lipidomics techniques have enabled the study of the complex lipid composition of adipose tissue and its role in metabolic disorders such as obesity, diabetes, and cardiovascular disease. In addition, adipose tissue lipidomics has emerged as a powerful tool for understanding the molecular mechanisms underlying these disorders and identifying bioactive lipid mediators and potential therapeutic targets. This review aims to summarize recent lipidomics studies that investigated the dynamic remodeling of adipose tissue lipids in response to specific physiological changes, pharmacological interventions, and pathological conditions. We discuss the molecular mechanisms of lipid remodeling in adipose tissue and explore the recent identification of bioactive lipid mediators generated in adipose tissue that regulate adipocytes and systemic metabolism. We propose that manipulating lipid-mediator metabolism could serve as a therapeutic approach for preventing or treating obesity-related metabolic diseases.
脂肪组织是一种活跃的代谢器官，在能量平衡和内分泌功能中起着至关重要的作用。最近脂质组学技术的进步使人们能够研究脂肪组织复杂的脂质组成及其在代谢紊乱（如肥胖症、糖尿病和心血管疾病）中的作用。此外，脂肪组织脂质组学已成为理解这些疾病分子机制以及鉴定生物活性脂质介质和潜在治疗靶点的有力工具。本综述旨在总结最近的脂质组学研究，这些研究调查了脂肪组织脂质对特定生理变化、药物干预和病理状况的动态重塑。我们讨论了脂肪组织中脂质重塑的分子机制，并探讨了最近在脂肪组织中鉴定到的生物活性脂质介质的产生，这些介质调节脂肪细胞和全身代谢。我们提出，操纵脂质介质代谢可能成为预防或治疗肥胖相关代谢性疾病的一种治疗方法。
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