Wang Kang-Ning, Li Zi-Zhan, Zhou Kan, Liu Bing, Rao Lang, Bu Lin-Lin
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Department of Oral & Maxillofacial-Head Neck Oncology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
Research (Wash D C). 2024 Sep 18;7:0478. doi: 10.34133/research.0478. eCollection 2024.
Dental, oral, and craniofacial diseases can substantially impact the quality of human life, thereby posing a serious public health concern. Although conventional therapies such as surgery have solved these problems largely, the prognosis of patients is not always satisfactory. Cell membrane-coated nanoparticles (CMCNPs) carry nanodrugs with the help of natural cell membranes, therefore utilizing their remarkable ability to interface and interact with their surrounding environment. These nanoparticles have demonstrated substantial advantages in drug targeting, prolonging blood circulation time, penetrating biofilms, and immune escape. With the assistance of CMCNPs, the therapeutic effects of dental, oral, and craniofacial diseases can reach a higher level. CMCNPs have been applied for dental, oral, and craniofacial diseases for various conditions such as head and neck cancer, periodontal disease, and oral biosignal detection. For the therapies of head and neck cancer, CMCNPs have been widely utilized as a tool of chemotherapy, phototherapy, and immunotherapy, while yet to be exploited in imaging technique. In the end, we summarized the challenges and prospectives of CMCNPs for dental, oral, and craniofacial diseases: large-scale production with uniform standards and high quantity, extensive application directions in dental, oral, and craniofacial regions (implant, endodontics), and the promotion of its clinical application.
牙齿、口腔和颅面疾病会严重影响人类生活质量，因此成为严重的公共卫生问题。尽管手术等传统疗法在很大程度上解决了这些问题，但患者的预后并不总是令人满意。细胞膜包覆纳米颗粒（CMCNPs）借助天然细胞膜携带纳米药物，从而利用其与周围环境进行界面接触和相互作用的卓越能力。这些纳米颗粒在药物靶向、延长血液循环时间、穿透生物膜和免疫逃逸方面已展现出显著优势。在CMCNPs的辅助下，牙齿、口腔和颅面疾病的治疗效果能够达到更高水平。CMCNPs已被应用于牙齿、口腔和颅面疾病的多种情况，如头颈癌、牙周病和口腔生物信号检测。对于头颈癌的治疗，CMCNPs已被广泛用作化疗、光疗和免疫治疗的工具，而在成像技术方面尚未得到开发。最后，我们总结了CMCNPs在牙齿、口腔和颅面疾病治疗中的挑战与前景：实现具有统一标准和高产量的大规模生产、在牙齿、口腔和颅面区域（植入、牙髓病学）有广泛的应用方向，以及推动其临床应用。
