局部应用阿昔洛韦治疗实验性单纯疱疹性角膜葡萄膜炎的效果。

Effect of topical acyclovir therapy on experimental herpes simplex keratouveitis.

作者信息

Maudgal P C, Vrijghem J C, Molemans M, Missotten L

出版信息

Arch Ophthalmol. 1985 Sep;103(9):1389-92. doi: 10.1001/archopht.1985.01050090141050.

DOI:10.1001/archopht.1985.01050090141050

Abstract

Stromal keratitis and associated iritis were produced in rabbit eyes with the intrastromal injection of live herpes simplex virus. Treatment with 3% acyclovir and 2% trifluridine eye ointments was initiated one day after infection and continued for five consecutive days. These therapies significantly suppressed the development of keratouveitis compared with a placebo ointment. The suppressive action of trifluridine ointment on keratouveitis was significantly more pronounced than that of acyclovir ointment.

摘要

通过基质内注射活的单纯疱疹病毒在兔眼诱发基质性角膜炎及相关虹膜炎。感染后一天开始用3%阿昔洛韦和2%三氟胸苷眼膏治疗，并持续连续五天。与安慰剂眼膏相比，这些疗法显著抑制了角膜葡萄膜炎的发展。三氟胸苷眼膏对角膜葡萄膜炎的抑制作用比阿昔洛韦眼膏更明显。