Children's Medical Center Research Institute, University of Texas (UT) Southwestern Medical Center, Dallas, TX, USA.
Children's Medical Center Research Institute, University of Texas (UT) Southwestern Medical Center, Dallas, TX, USA; Howard Hughes Medical Institute, UT Southwestern Medical Center, Dallas, TX, USA.
Trends Cancer. 2021 Aug;7(8):700-713. doi: 10.1016/j.trecan.2021.04.007. Epub 2021 May 19.
Neutrophils, the most abundant leukocyte population in humans, constantly patrol the body for foreign cells, including pathogens and cancer cells. Once neutrophils are activated, they engage distinct metabolic pathways to fulfill their specialized antipathogen functions. In this review, we examine current research on the metabolism of neutrophil differentiation and antipathogen responses. We also discuss how tumor-associated neutrophils (TANs) can be educated by cytokines and by the nutrient-restrictive milieu of the tumor microenvironment (TME) to suppress antitumor immunity, promote cancer progression, and contribute to biological heterogeneity among tumors. Last, we discuss the clinical implications of circulating neutrophils and infiltrating TANs and consider how targeting TAN metabolism may synergize with cancer immunotherapy.
中性粒细胞是人体中最丰富的白细胞群体，它们不断巡逻身体，寻找包括病原体和癌细胞在内的外来细胞。一旦中性粒细胞被激活，它们就会利用不同的代谢途径来完成其专门的抗病原体功能。在这篇综述中，我们研究了中性粒细胞分化和抗病原体反应的代谢的最新研究。我们还讨论了肿瘤相关中性粒细胞（TAN）如何被细胞因子和肿瘤微环境（TME）的营养限制环境所“教育”，从而抑制抗肿瘤免疫、促进癌症进展，并导致肿瘤之间的生物学异质性。最后，我们讨论了循环中性粒细胞和浸润性 TAN 的临床意义，并考虑了靶向 TAN 代谢如何与癌症免疫治疗协同作用。
