Persson L, Oredsson S M, Anehus S, Heby O
Biochem Biophys Res Commun. 1985 Aug 30;131(1):239-45. doi: 10.1016/0006-291x(85)91794-2.
Ehrlich ascites tumor cells grown in the presence of inhibitors of ornithine decarboxylase (EC 4.1.1.17) exhibited an elevated content of this enzyme. The increase could not solely be explained by a decrease in the degradation rate of the enzyme. Instead a stimulation of enzyme synthesis, probably mediated via the polyamine-depleting properties of the inhibitors, is suggested. The enhancement of cellular ornithine decarboxylase content was not accompanied by any significant changes in the amount of ornithine decarboxylase mRNA, indicating a regulation at the level of translation.
在鸟氨酸脱羧酶（EC 4.1.1.17）抑制剂存在的情况下培养的艾氏腹水癌细胞，该酶的含量有所升高。这种增加不能仅仅用酶降解速率的降低来解释。相反，有人提出可能是通过抑制剂的多胺耗竭特性介导的酶合成受到了刺激。细胞内鸟氨酸脱羧酶含量的增加并没有伴随着鸟氨酸脱羧酶mRNA量的任何显著变化，这表明在翻译水平上存在调控。
