要阻断培养中的艾氏腹水癌细胞增殖，需要对生长刺激后鸟氨酸脱羧酶活性的早期增加进行不可逆抑制。 - Suppr

Suppr

超能文献

Irreversible inhibition of the early increase in ornithine decarboxylase activity following growth stimulation is required to block Ehrlich ascites tumor cell proliferation in culture.

作者信息

Oredsson S, Anehus S, Heby O

出版信息

Biochem Biophys Res Commun. 1980 May 14;94(1):151-8. doi: 10.1016/s0006-291x(80)80200-2.

DOI:10.1016/s0006-291x(80)80200-2

PMID:6770860

Abstract

摘要

相似文献

Irreversible inhibition of the early increase in ornithine decarboxylase activity following growth stimulation is required to block Ehrlich ascites tumor cell proliferation in culture.要阻断培养中的艾氏腹水癌细胞增殖，需要对生长刺激后鸟氨酸脱羧酶活性的早期增加进行不可逆抑制。

Biochem Biophys Res Commun. 1980 May 14;94(1):151-8. doi: 10.1016/s0006-291x(80)80200-2.

Role of polyamines in the proliferation and steroidogenic activities of bovine adrenocortical cells in culture.多胺在体外培养的牛肾上腺皮质细胞增殖和类固醇生成活性中的作用

Biochem Biophys Res Commun. 1981 Dec 31;103(4):1294-301. doi: 10.1016/0006-291x(81)90263-1.

Anti-proliferative properties of DL-alpha-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase.DL-α-二氟甲基鸟氨酸在培养细胞中的抗增殖特性。鸟氨酸脱羧酶不可逆抑制的结果。

Biochem Biophys Res Commun. 1978 Mar 15;81(1):58-66. doi: 10.1016/0006-291x(78)91630-3.

Polyamine depletion induces enhanced synthesis and accumulation of cadaverine in cultured Ehrlich ascites carcinoma cells.多胺耗竭诱导培养的艾氏腹水癌细胞中尸胺的合成和积累增强。

Biochem Biophys Res Commun. 1980 Apr 29;93(4):1005-13. doi: 10.1016/0006-291x(80)90589-6.

Ovarian function in the rat following irreversible inhibition of L-ornithine decarboxylase.L-鸟氨酸脱羧酶不可逆抑制后大鼠的卵巢功能

Life Sci. 1980 Dec 8;27(23):2277-83. doi: 10.1016/0024-3205(80)90395-1.

Effect of inhibitors on ornithine and adenosylmethionine decarboxylases on the synthesis of deoxyribonucleic acid in Ehrlich ascites cells in vivo.鸟氨酸脱羧酶和腺苷甲硫氨酸脱羧酶抑制剂对艾氏腹水癌细胞体内脱氧核糖核酸合成的影响。

Acta Chem Scand B. 1979;33(8):559-66. doi: 10.3891/acta.chem.scand.33b-0559.

Inhibition of cell proliferation by DL-alpha-difluoromethylornithine, a catalytic irreversible inhibitor of ornithine decarboxylase.DL-α-二氟甲基鸟氨酸（一种鸟氨酸脱羧酶的催化性不可逆抑制剂）对细胞增殖的抑制作用。

Acta Chem Scand B. 1980;34(6):457-8. doi: 10.3891/acta.chem.scand.34b-0457.

Depletion of intracellular putrescine and spermidine by alpha-difluromethylornithine does not inhibit proliferation of 9L rat brain tumor cells.α-二氟甲基鸟氨酸耗尽细胞内的腐胺和亚精胺并不抑制9L大鼠脑肿瘤细胞的增殖。

Biochem Biophys Res Commun. 1979 Feb 28;86(4):1192-8. doi: 10.1016/0006-291x(79)90243-2.

Inhibition of ornithine decarboxylase activity and cell growth by diamines: a comparison between the effects of two homologs, 1,3-diaminopropane and 1,4-diaminobutane (putrescine).二胺对鸟氨酸脱羧酶活性和细胞生长的抑制作用：两种同系物1,3 - 二氨基丙烷和1,4 - 二氨基丁烷（腐胺）作用效果的比较

J Cell Biochem. 1985;29(2):105-13. doi: 10.1002/jcb.240290206.

Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on polyamine levels in rat tissues.α-二氟甲基鸟氨酸（一种鸟氨酸脱羧酶的酶激活不可逆抑制剂）对大鼠组织中多胺水平的影响。

Life Sci. 1979 Feb 5;24(6):519-24. doi: 10.1016/0024-3205(79)90173-5.

引用本文的文献

Diethylglyoxal bis(guanylhydrazone), a potent inhibitor of mammalian S-adenosylmethionine decarboxylase. Effects on cell proliferation and polyamine metabolism in L1210 leukemia cells.二乙二醛双（胍基腙），一种有效的哺乳动物S-腺苷甲硫氨酸脱羧酶抑制剂。对L1210白血病细胞增殖和多胺代谢的影响。

Mol Cell Biochem. 1993 Jul 21;124(2):141-7. doi: 10.1007/BF00929206.

Polyamine starvation prolongs the S and G2 phases of polyamine-dependent (arginase-deficient) CHO cells.多胺饥饿延长了多胺依赖性（精氨酸酶缺陷型）中国仓鼠卵巢细胞的S期和G2期。

Mol Cell Biol. 1984 May;4(5):915-22. doi: 10.1128/mcb.4.5.915-922.1984.

Reversal of the growth inhibitory effect of alpha-difluoromethylornithine by putrescine but not by other divalent cations.腐胺可逆转α-二氟甲基鸟氨酸的生长抑制作用，而其他二价阳离子则不能。

Mol Cell Biochem. 1984 Sep;64(2):163-72. doi: 10.1007/BF00224773.

Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat.多胺生物合成是维持大鼠外周血细胞成分所必需的。

Proc Natl Acad Sci U S A. 1983 Aug;80(16):5090-3. doi: 10.1073/pnas.80.16.5090.

Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells.环磷酸腺苷（cAMP）耗竭和多胺耗竭对培养的小鼠淋巴瘤细胞生长的调节作用是可分离的。

J Cell Biol. 1983 Mar;96(3):762-7. doi: 10.1083/jcb.96.3.762.

The chemotherapeutic potential of polyamine antimetabolites.多胺抗代谢物的化疗潜力。

Ann R Coll Surg Engl. 1986 Mar;68(2):76-81.

Differential stimulation of S-adenosylmethionine decarboxylase by difluoromethylornithine in the rat colon and small intestine.二氟甲基鸟氨酸对大鼠结肠和小肠中S-腺苷甲硫氨酸脱羧酶的差异刺激作用。

Biochem J. 1989 Apr 15;259(2):513-8. doi: 10.1042/bj2590513.

Feedback control of ornithine decarboxylase expression by polyamines. Analysis of ornithine decarboxylase mRNA distribution in polysome profiles and of translation of this mRNA in vitro.多胺对鸟氨酸脱羧酶表达的反馈控制。鸟氨酸脱羧酶mRNA在多核糖体图谱中的分布分析及其体外翻译分析。

Biochem J. 1989 Mar 1;258(2):343-50. doi: 10.1042/bj2580343.

Immunocytochemical localization of ornithine decarboxylase in cultured murine cells.鸟氨酸脱羧酶在培养的鼠细胞中的免疫细胞化学定位

Cell Tissue Res. 1986;243(1):33-40. doi: 10.1007/BF00221849.

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