Department of Biomedical Engineering, School of ICT Convergence Engineering, College of Science & Technology, Konkuk University, Chungju-si, Chungcheongbuk-do, Republic of Korea.
Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, Songpa-gu, Seoul, Republic of Korea.
PLoS One. 2024 Sep 19;19(9):e0308691. doi: 10.1371/journal.pone.0308691. eCollection 2024.
This study reports the effects of changes in the waveform and frequency of radio frequency (RF) energy on the tissue ablation range. We developed a 70-watt RFA generator that provides sine and square waves and allows frequency control between 10 Hz and 500 kHz. The changes in the ablation range according to the waveform and frequency were observed using the developed generator. In the waveform variation test, the distance between the electrodes and the electrode type were changed for both waveforms with the frequency set to 500 kHz. In the frequency variation test, the waveform and electrode type were changed with the frequency set to 10, 100, and 500 kHz, while the distance between the electrodes was set to 20 mm. A fixed 45 voltage was applied using the bipolar method. RF energy was applied for 90 s in vitro. The temperature was regulated to not exceed 70°C. The ablation range was calculated using ImageJ software. The analysis results showed that the ablation range was larger with the square wave than with the sine wave and at 10 kHz than at 500 kHz. The developed generator can advance research on ablation area and depth in RF ablation.
本研究报告了改变射频 (RF) 能量的波形和频率对组织消融范围的影响。我们开发了一种 70 瓦的 RFA 发生器，它提供正弦波和方波，并允许在 10 Hz 至 500 kHz 之间进行频率控制。使用开发的发生器观察了根据波形和频率的消融范围变化。在波形变化测试中，在频率设置为 500 kHz 的情况下，对于两种波形，改变了电极之间的距离和电极类型。在频率变化测试中，改变了波形和电极类型，频率设置为 10、100 和 500 kHz，而电极之间的距离设置为 20 mm。使用双极法施加固定的 45 伏特电压。在体外应用 RF 能量 90 秒。将温度调节至不超过 70°C。使用 ImageJ 软件计算消融范围。分析结果表明，与正弦波相比，方波的消融范围更大，与 500 kHz 相比，10 kHz 的消融范围更大。所开发的发生器可以推进 RF 消融中消融区域和深度的研究。
