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伊希尔丁库,用于高效求解兴奋介质各向异性反应扩散问题的数值解。

The Ithildin library for efficient numerical solution of anisotropic reaction-diffusion problems in excitable media.

机构信息

Department of Mathematics, KU Leuven Campus Kortrijk (KULAK), Kortrijk, Belgium.

Laboratory of Experimental Cardiology, Leiden University Medical Center (LUMC), Leiden, The Netherlands.

出版信息

PLoS One. 2024 Sep 19;19(9):e0303674. doi: 10.1371/journal.pone.0303674. eCollection 2024.

Abstract

Ithildin is an open-source library and framework for efficient parallelized simulations of excitable media, written in the C++ programming language. It uses parallelization on multiple CPU processors via the message passing interface (MPI). We demonstrate the library's versatility through a series of simulations in the context of the monodomain description of cardiac electrophysiology, including the S1S2 protocol, spiral break-up, and spiral waves in ventricular geometry. Our work demonstrates the power of Ithildin as a tool for studying complex wave patterns in cardiac tissue and its potential to inform future experimental and theoretical studies. We publish our full code with this paper in the name of open science.

摘要

Ithildin 是一个用于兴奋介质高效并行模拟的开源库和框架,使用 C++编程语言编写。它通过消息传递接口 (MPI) 在多个 CPU 处理器上进行并行化。我们通过一系列在心脏电生理学的单域描述背景下的模拟展示了该库的多功能性,包括 S1S2 协议、螺旋破裂和心室几何中的螺旋波。我们的工作展示了 Ithildin 作为研究心脏组织中复杂波型的工具的强大功能及其为未来实验和理论研究提供信息的潜力。我们以开放科学的名义在本文中发布了完整的代码。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b818/11412660/bd59d2011656/pone.0303674.g001.jpg

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