Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., Warsaw 02-093, Poland.
Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., Warsaw 02-093, Poland.
J Pharm Biomed Anal. 2025 Jan 1;252:116474. doi: 10.1016/j.jpba.2024.116474. Epub 2024 Sep 16.
N-Phenylacetyl-L-prolylglycine ethyl ester (Noopept, GVS-111, omberacetam) is an orally available active pharmaceutical ingredient (API), with neuroprotective properties and ability to enhance cognitive function. It belongs to nootropic family of drugs and is included in the group of racetams, although its chemical structure is quite different than the other compounds from this group, including the most popular one - piracetam. The mechanism of action of this API is multifaced and is considered to be involving modulation of various neurotransmitter systems within the brain. Despite the significant amount of works devoted to the pharmacodynamics of Noopept, very little is known about its structural and physicochemical properties. Therefore, the aim of current study was to investigate this API in a very thorough way. In this work, the detailed physicochemical analysis of Noopept has been done using TGA/DSC, H and C liquid state NMR, C CP/MAS NMR, SEM, SCXRD, and PXRD. Additionally, quantum chemical DFT computations under periodic boundary conditions, using CASTEP, were conducted to facilitate the analysis of experimental results. Besides, we've performed a polymorphism screening of this molecule.
N-苯乙酰-L-脯氨酰甘氨酸乙酯（Noopept、GVS-111、奥贝莫泮）是一种可口服的活性药物成分（API），具有神经保护特性和增强认知功能的能力。它属于益智药家族的药物，属于吡拉西坦类药物，尽管其化学结构与该组中的其他化合物（包括最受欢迎的吡拉西坦）有很大不同。该 API 的作用机制是多方面的，被认为涉及调节大脑内的各种神经递质系统。尽管已经有大量工作致力于研究 Noopept 的药效学，但对其结构和物理化学性质却知之甚少。因此，目前的研究旨在非常彻底地研究该 API。在这项工作中，使用 TGA/DSC、H 和 C 液态 NMR、C CP/MAS NMR、SEM、SCXRD 和 PXRD 对 Noopept 进行了详细的物理化学分析。此外，还使用 CASTEP 进行了基于周期性边界条件的量子化学 DFT 计算，以帮助分析实验结果。除此之外，我们还对该分子进行了多态性筛选。
