Department of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy.
Department of Veterinary Anatomy Physiology and Pathology, Institute of Infection, Veterinary and Ecological Science, Faculty of Health and life Science, University of Liverpool, Chester High Road, Neston CH64 7TE, United Kingdom.
Res Vet Sci. 2024 Nov;180:105411. doi: 10.1016/j.rvsc.2024.105411. Epub 2024 Sep 13.
The cannabinoid 2 receptor (CB2R) is a crucial element of the endocannabinoid system (ECS), which is predominantly expressed on cells of the reticuloendothelial system. Alterations in CB2R expression have shown a prognostic role in various human neoplastic diseases and its expression has been studied in canine mast cell tumours (MCT). Canine diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in dogs and has a variable clinical behaviour. Expression of CB2R was assessed by means of immunohistochemistry in fifteen dogs with proven histological diagnosis of DLBCL. A semiquantitative and quantitative assessment of immunoreactivity (IR) by digital analysis was performed in all cases. Our results indicate that CB2R expression is conserved in canine DLBCL but does not correlate with clinical outcome.
大麻素 2 型受体（CB2R）是内源性大麻素系统（ECS）的关键组成部分，主要表达在网状内皮系统的细胞上。CB2R 表达的改变已显示在各种人类肿瘤性疾病中具有预后作用，并且已在犬肥大细胞瘤（MCT）中对其表达进行了研究。犬弥漫性大 B 细胞淋巴瘤（DLBCL）是犬中最常见的淋巴瘤，具有不同的临床行为。通过免疫组织化学方法评估了 15 只经组织学证实为 DLBCL 的犬的 CB2R 表达情况。对所有病例均进行了数字分析的免疫反应性（IR）半定量和定量评估。我们的结果表明，CB2R 在犬 DLBCL 中表达保持不变，但与临床结果无关。
