个体化睡眠和营养策略以应对夜班工作的不良影响：一项对照干预方案。
Personalized sleep and nutritional strategies to combat adverse effects of night shift work: a controlled intervention protocol.
机构信息
Department of Public Health, Erasmus MC, Rotterdam, 3000 CA, The Netherlands.
Research Group Microbiology & Systems Biology, TNO, Organization for Applied Scientific Research, Leiden, 2333 BE, The Netherlands.
出版信息
BMC Public Health. 2024 Sep 19;24(1):2555. doi: 10.1186/s12889-024-20022-w.
BACKGROUND
Working during the night interferes with the timing of normal daily activities and is associated with an increased risk of chronic diseases. Under controlled experimental conditions, interventions focusing on sleep and nutrition can mitigate the short-term adverse effects of shift work. However, it is unclear how these results translate to real-life, how they can be targeted to individual conditions, and how they relate to long-term health. Therefore, the current study aims to implement a personalized sleep and nutritional intervention among night shift workers in the field.
METHODS
A non-blinded controlled intervention study is used, consisting of a run-in period, an intervention of 3 months, post-intervention measurements, and a follow-up after 12 months. Three study arms are included: sleep intervention, nutritional intervention, and control group (n = 25 each). Participants are healthy 18-60-year male night shift workers, with at least one year of experience in night shift work. Information from the run-in period will be used to personalize the interventions. The main outcomes are sleep measurements and continuous interstitial glucose levels. Furthermore, general health biomarkers and parameters will be determined to further evaluate effects on long-term health.
DISCUSSION
This study aims to mitigate negative health consequences associated with night shift work by introducing two personalized preventive interventions. If proven effective, the personalized interventions may serve as practical solutions that can have a meaningful impact on the sustainable health and employability of night shift workers. This study will thereby contribute to the current need for high-quality data on preventative strategies for night shift work in a real-life context.
TRIAL REGISTRATION
This trial has been registered under ClinicalTrials.gov Identifier NCT06147089. Registered 27 November 2023.
背景
夜间工作会干扰正常的日常活动时间安排，并增加患慢性病的风险。在受控的实验条件下，侧重于睡眠和营养的干预措施可以减轻轮班工作的短期不良影响。然而，目前尚不清楚这些结果如何转化为现实生活，如何针对个体情况进行针对性干预，以及它们与长期健康的关系。因此，本研究旨在现场实施针对夜班工人的个性化睡眠和营养干预措施。
方法
本研究采用非盲对照干预研究，包括预试验期、为期 3 个月的干预期、干预后测量期和 12 个月随访期。共纳入 3 个研究组：睡眠干预组、营养干预组和对照组（每组 25 人）。参与者为健康的 18-60 岁男性夜班工人，具有至少一年的夜班工作经验。预试验期的信息将用于个性化干预措施。主要结局指标是睡眠测量和连续间质葡萄糖水平。此外，还将确定一般健康生物标志物和参数，以进一步评估对长期健康的影响。
讨论
本研究旨在通过引入两种个性化预防干预措施来减轻与夜班工作相关的负面健康后果。如果被证明有效，个性化干预措施可能成为实用的解决方案，可以对夜班工人的可持续健康和就业能力产生有意义的影响。本研究将有助于满足当前对现实生活中夜班工作预防策略的高质量数据的需求。
试验注册
本试验已在 ClinicalTrials.gov 标识符 NCT06147089 下注册。注册日期为 2023 年 11 月 27 日。
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