Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, D-17475, Greifswald, Germany.
DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.
Lipids Health Dis. 2024 Sep 19;23(1):302. doi: 10.1186/s12944-024-02290-y.
Dyslipidemia has been associated with reduced bone mineral density and osteoporotic fractures, but the relation between lipid and bone metabolism remains poorly understood. Analysing the effects of lipoprotein subclasses on bone turnover may provide valuable insights into this association. We therefore examined whether lipoprotein subclasses, measured by proton nuclear magnetic resonance (H-NMR) spectroscopy, are associated with bone turnover markers (BTMs) and with the ultrasound-based bone stiffness index.
Data from 1.349 men and 1.123 women, who participated in the population-based Study of Health in Pomerania-TREND were analysed. Serum intact amino-terminal propeptide of type I procollagen (P1NP, bone formation) and carboxy-terminal telopeptide of type I collagen (CTX, bone resorption) concentrations were measured. Associations between the lipoprotein data and the BTMs or the stiffness index were investigated using linear regression models.
The triglyceride or cholesterol content in very-low-density lipoprotein and intermediate-density lipoprotein particles was inversely associated with both BTMs, with effect estimates being slightly higher for CTX than for P1NP. The triglyceride content in low-density lipoprotein and high-density lipoprotein particles and the Apo-A2 content in high-density lipoprotein particles was further inversely associated with the BTMs. Associations with the ultrasound-based bone stiffness index were absent.
Consistent inverse associations of triglycerides with bone turnover were observed, which argue for a protective effect on bone health, at least in the normal range. Yet, the presented associations did not translate into effects on the ultrasound-based bone stiffness. Further, there was no relevant gain of information by assessing the lipoprotein subclasses. Nevertheless, our study highlights the close relations between lipid and bone metabolism in the general population.
血脂异常与骨密度降低和骨质疏松性骨折有关，但脂质和骨代谢之间的关系仍知之甚少。分析脂蛋白亚类对骨转换的影响可能为这种关联提供有价值的见解。因此，我们研究了通过质子磁共振（H-NMR）光谱测量的脂蛋白亚类是否与骨转换标志物（BTM）以及基于超声的骨硬度指数相关。
对参加基于人群的波美拉尼亚趋势研究的 1349 名男性和 1123 名女性的数据进行了分析。测量了血清完整氨基末端原胶原 I 型前肽（骨形成的 P1NP）和 I 型胶原羧基末端肽（骨吸收的 CTX）浓度。使用线性回归模型研究了脂蛋白数据与 BTM 或硬度指数之间的关联。
极低密度脂蛋白和中间密度脂蛋白颗粒中的甘油三酯或胆固醇含量与两种 BTM 呈负相关，CTX 的效应估计值略高于 P1NP。低密度脂蛋白和高密度脂蛋白颗粒中的甘油三酯含量以及高密度脂蛋白颗粒中的 Apo-A2 含量与 BTM 进一步呈负相关。与基于超声的骨硬度指数无关联。
观察到甘油三酯与骨转换之间一致的负相关，这表明在正常范围内对骨骼健康具有保护作用。然而，这些关联并未转化为基于超声的骨硬度的影响。此外，评估脂蛋白亚类并没有提供相关的信息增益。尽管如此，我们的研究强调了人群中脂质和骨代谢之间的密切关系。
