Bhowmik Shubham, Mehra Lalita, Ghosh Tamoghna, Akhtar Sagir, Tiwari Ashok, Dutta Rimlee, Kedia Saurav, Yadav Rajni, Makharia Govind K, Ahuja Vineet, Das Prasenjit
Department of Pathology, All India Institute of Medical Sciences, New Delhi, DL, India.
Department of Gastroenterology All India Institute of Medical Sciences, New Delhi, DL, India.
Int J Surg Pathol. 2025 May;33(3):516-527. doi: 10.1177/10668969241271352. Epub 2024 Sep 19.
Basic differentiation between an inflammatory bowel disease (IBD)-type colitis and a non-IBD type of colitis is the essential histological pre-requisite before further subclassifications are made. The combination of mucosal prominent eosinophilic cell infiltrate along with basal plasmacytosis is supposed to be a useful histological feature that can differentiate between IBD-type and non-IBD-type colitis. Hence, this systematic review and metaanalysis aimed to assess the reliability of mucosal basal plasmacytosis and eosinophilia for histological differentiation of IBD-type versus non-IBD-type colitis. We searched the PROSPERO, PubMed, Embase, and Scopus from January 1, 2000 to July 30, 2022 for all types of studies (prospective, cross-sectional, or retrospective studies) having histological features (including mucosal basal plasmacytosis, eosinophilia, and neutrophilic infiltration) in IBD and/or non-IBD colitis cases. Two reviewers extracted data, which were aggregated using random-effects models. The 59 selected articles were evaluated for the predecided parameters. Both basal plasmacytosis and lamina propria plasmacytosis did not show any significant correlation between IBD-type and non-IBD-type colitis. The proportions for basal plasmacytosis with 95% CI were 0.50 (0.19-0.82) in IBD-type colitis and 0.46 (0.40-0.52) in non-IBD-type colitis, with a value of .79. The proportion of lamina propria plasmacytosis with 95% CI was 0.67 (0.42-0.92) in IBD and 0.60 (0.35-0.85) in non-IBD-type colitis, with a value being .7. This systematic review documented the dearth of published data on key histological features such as basal plasmacytosis and mucosal eosinophilia which are believed to differentiate between IBD-type and non-IBD-type colitis.
在进行进一步的亚分类之前，区分炎症性肠病（IBD）型结肠炎和非IBD型结肠炎是必要的组织学前提。黏膜显著嗜酸性粒细胞浸润与基底浆细胞增多相结合被认为是区分IBD型和非IBD型结肠炎的有用组织学特征。因此，本系统评价和荟萃分析旨在评估黏膜基底浆细胞增多和嗜酸性粒细胞增多在IBD型与非IBD型结肠炎组织学鉴别中的可靠性。我们检索了2000年1月1日至2022年7月30日期间的PROSPERO、PubMed、Embase和Scopus数据库，查找所有具有IBD和/或非IBD结肠炎病例组织学特征（包括黏膜基底浆细胞增多、嗜酸性粒细胞增多和中性粒细胞浸润）的研究类型（前瞻性、横断面或回顾性研究）。两名审阅者提取数据，并使用随机效应模型进行汇总。对59篇选定的文章进行了预先确定参数的评估。基底浆细胞增多和固有层浆细胞增多在IBD型和非IBD型结肠炎之间均未显示出任何显著相关性。IBD型结肠炎中基底浆细胞增多的比例及95%置信区间为0.50（0.19 - 0.82），非IBD型结肠炎中为0.46（0.40 - 0.52），P值为0.79。IBD中固有层浆细胞增多的比例及95%置信区间为0.67（0.42 - 0.92），非IBD型结肠炎中为0.60（0.35 - 0.85），P值为0.7。本系统评价记录了关于基底浆细胞增多和黏膜嗜酸性粒细胞增多等关键组织学特征的已发表数据匮乏，而这些特征被认为可区分IBD型和非IBD型结肠炎。
