Wallace H. Coulter Department of Biomedical Engineering, Emory University, Atlanta, Georgia 30345, United States.
Department of Chemical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.
ACS Synth Biol. 2024 Sep 20;13(9):2635-2642. doi: 10.1021/acssynbio.4c00276.
The Cold Spring Harbor Laboratory (CSHL) Summer Course on Synthetic Biology, established in 2013, has emerged as a premier platform for immersive education and research in this dynamic field. Rooted in CSHL's rich legacy of biological discovery, the course offers a comprehensive exploration of synthetic biology's fundamentals and applications. Led by a consortium of faculty from diverse institutions, the course structure seamlessly integrates practical laboratory sessions, exploratory research rotations, and enriching seminars by leaders in the field. Over the years, the curriculum has evolved to cover essential topics such as cell-free transcription-translation, DNA construction, computational modeling of gene circuits, engineered gene regulation, and CRISPR technologies. In this review, we describe the history, development, and structure of the course, and discuss how elements of the course might inform the development of other short courses in synthetic biology. We also demonstrate the course's impact beyond the lab with a summary of alumni contributions to research, education, and entrepreneurship. Through these efforts, the CSHL Summer Course on Synthetic Biology remains at the forefront of shaping the next generation of synthetic biologists.
冷泉港实验室（CSHL）合成生物学暑期课程成立于 2013 年，已成为该领域沉浸式教育和研究的首要平台。该课程植根于 CSHL 在生物学发现方面的丰富传统，全面探索了合成生物学的基础和应用。由来自不同机构的教师联盟领导，课程结构将实用的实验室课程、探索性研究轮换以及该领域领导者的丰富研讨会无缝融合。多年来，课程不断发展，涵盖了细胞游离转录翻译、DNA 构建、基因回路的计算建模、工程基因调控和 CRISPR 技术等重要主题。在这篇综述中，我们描述了课程的历史、发展和结构，并讨论了课程的哪些要素可以为其他合成生物学短期课程的发展提供信息。我们还通过总结校友对研究、教育和创业的贡献，展示了课程在实验室之外的影响。通过这些努力，CSHL 合成生物学暑期课程始终处于塑造下一代合成生物学家的前沿。
