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本文引用的文献

1
Spinal Cord Stimulation With "Conventional Clinical" and Higher Frequencies on Activity and Responses of Spinal Neurons to Noxious Stimuli: An Animal Study.“传统临床”及更高频率脊髓刺激对脊髓神经元活动及对伤害性刺激反应的影响：一项动物研究
Neuromodulation. 2018 Jul;21(5):440-447. doi: 10.1111/ner.12725. Epub 2017 Nov 22.
2
Spinal Cord Stimulation for Treating Chronic Pain: Reviewing Preclinical and Clinical Data on Paresthesia-Free High-Frequency Therapy.脊髓刺激治疗慢性疼痛：回顾无感觉异常高频疗法的临床前和临床数据
Neuromodulation. 2018 Jan;21(1):10-18. doi: 10.1111/ner.12721. Epub 2017 Nov 3.
3
A review of spinal cord stimulation systems for chronic pain.慢性疼痛脊髓刺激系统综述
J Pain Res. 2016 Jul 1;9:481-92. doi: 10.2147/JPR.S108884. eCollection 2016.
4
Parameters of Spinal Cord Stimulation and Their Role in Electrical Charge Delivery: A Review.脊髓刺激参数及其在电刺激中的作用：综述。
Neuromodulation. 2016 Jun;19(4):373-84. doi: 10.1111/ner.12438. Epub 2016 May 6.
5
Relevant Anatomic and Morphological Measurements of the Rat Spine: Considerations for Rodent Models of Human Spine Trauma.大鼠脊柱的相关解剖学和形态学测量：人类脊柱创伤啮齿动物模型的考量因素
Spine (Phila Pa 1976). 2015 Oct 15;40(20):E1084-92. doi: 10.1097/BRS.0000000000001021.
6
Computational analysis of kilohertz frequency spinal cord stimulation for chronic pain management.用于慢性疼痛管理的千赫兹频率脊髓刺激的计算分析。
Anesthesiology. 2015 Jun;122(6):1362-76. doi: 10.1097/ALN.0000000000000649.
7
Efficacy of kilohertz-frequency and conventional spinal cord stimulation in rat models of different pain conditions.千赫兹频率与传统脊髓刺激对不同疼痛状态大鼠模型的疗效。
Neuromodulation. 2014 Apr;17(3):226-34; discussion 234-5. doi: 10.1111/ner.12161. Epub 2014 Feb 25.
8
Conventional and kilohertz-frequency spinal cord stimulation produces intensity- and frequency-dependent inhibition of mechanical hypersensitivity in a rat model of neuropathic pain.常规和千赫兹频率脊髓刺激在神经病理性疼痛的大鼠模型中产生强度和频率依赖性的机械性痛觉过敏抑制。
Anesthesiology. 2013 Aug;119(2):422-32. doi: 10.1097/ALN.0b013e31829bd9e2.
9
Spinal cord stimulation in pain management: a review.脊髓刺激在疼痛管理中的应用：综述。
Korean J Pain. 2012 Jul;25(3):143-50. doi: 10.3344/kjp.2012.25.3.143. Epub 2012 Jun 28.
10
Which Neuronal Elements are Activated Directly by Spinal Cord Stimulation.哪些神经元直接受脊髓刺激激活。
Neuromodulation. 2002 Jan;5(1):25-31. doi: 10.1046/j.1525-1403.2002._2005.x.

在啮齿动物的硬膜外脊髓刺激过程中坐骨神经的激活。

Activation of the sciatic nerve evoked during epidural spinal cord stimulation in rodents.

作者信息

Bhadra Narendra, Vrabec Tina, Kilgore Kevin, Bhadra Niloy

机构信息

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.

Metro Health Medical Center, Cleveland, OH 44109, USA.

出版信息

Bioelectron Med (Lond). 2019;2(2):63-71. doi: 10.2217/bem-2019-0020. Epub 2019 Oct 4.

DOI:10.2217/bem-2019-0020
PMID:39301011
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11412300/
Abstract

AIM

To validate the use of motor activation thresholds (MoT) to titrate stimulation amplitudes for spinal cord stimulation in rodent models.

METHODS

We recorded thresholds for MoT and sciatic compound action potentials in ten Sprague-Dawley rats implanted with epidural electrodes. Strength duration curves were fitted to the threshold values.

RESULTS

Activation thresholds were in the same order for both MoT and sciatic compound action potentials.

CONCLUSION

Many of the large, myelinated fibers traversing the dorsal columns in the rodent spine are activated at similar current levels to MoT. Epidural stimulation in rodents needs to be applied at amplitudes close to MoT to activate these axons.

摘要

目的

验证在啮齿动物模型中使用运动激活阈值（MoT）来滴定脊髓刺激的刺激幅度。

方法

我们记录了10只植入硬膜外电极的Sprague-Dawley大鼠的MoT阈值和坐骨复合动作电位。对阈值进行强度-时间曲线拟合。

结果

MoT和坐骨复合动作电位的激活阈值顺序相同。

结论

许多穿过啮齿动物脊柱背柱的大的有髓纤维在与MoT相似的电流水平下被激活。在啮齿动物中进行硬膜外刺激时，需要以接近MoT的幅度施加刺激以激活这些轴突。