Department of Dermatology, Huashan Hosptial, Fudan University, Shanghai, China.
iHuman Institute, ShanghaiTech University, Shanghai, China.
Front Immunol. 2024 Sep 5;15:1448952. doi: 10.3389/fimmu.2024.1448952. eCollection 2024.
Protease-activated receptor-2 (PAR2) is a class-A G protein-coupled receptor (GPCR) activated by serine proteases and is expressed by multiple tissues, including the skin. PAR2 is involved in the skin inflammatory response, promoting Th2 inflammation, delaying skin barrier repair, and affecting the differentiation of keratinocytes. It also participates in the transmission of itch and pain sensations in the skin. Increasing evidence indicates that PAR2 plays an important role in the pathogenesis of inflammatory skin diseases such as acne vulgaris, rosacea, psoriasis, and atopic dermatitis. Additional focus will be placed on potential targeted therapies based on PAR2. The Goal of this review is to outline the emerging effects of PAR2 activation in inflammatory skin disease and highlight the promise of PAR2 modulators.
蛋白酶激活受体 2（PAR2）是一种 A 类 G 蛋白偶联受体（GPCR），可被丝氨酸蛋白酶激活，表达于多种组织，包括皮肤。PAR2 参与皮肤炎症反应，促进 Th2 炎症，延迟皮肤屏障修复，并影响角质形成细胞的分化。它还参与皮肤瘙痒和疼痛感觉的传递。越来越多的证据表明，PAR2 在痤疮、酒渣鼻、银屑病和特应性皮炎等炎症性皮肤病的发病机制中起重要作用。研究重点还将放在基于 PAR2 的潜在靶向治疗上。本文旨在概述 PAR2 激活在炎症性皮肤病中的新作用，并强调 PAR2 调节剂的应用前景。
