Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease Related Molecular Network and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Front Immunol. 2024 Sep 19;15:1449126. doi: 10.3389/fimmu.2024.1449126. eCollection 2024.
Protease-activated receptor 2 (PAR2) is a cell-surface receptor expressed in various cell types, including keratinocytes, neurons, immune and inflammatory cells. Activation of PAR2, whether via its canonical or biased pathways, triggers a series of signaling cascades that mediate numerous functions. This review aims to highlight the emerging roles and interactions of PAR2 in different skin cells. It specifically summarizes the latest insights into the roles of PAR2 in skin conditions such as atopic dermatitis (AD), psoriasis, vitiligo and melasma. It also considers these roles from the perspective of the cutaneous microenvironment in relation to other inflammatory and autoimmune dermatological disorders. Additionally, the review explores PAR2's involvement in associated comorbidities from both cutaneous and extracutaneous diseases. Therefore, PAR2 may serve as a key target for interactions among various cells within the local skin environment.
蛋白酶激活受体 2 (PAR2) 是一种表达在多种细胞类型中的细胞表面受体，包括角质形成细胞、神经元、免疫和炎症细胞。PAR2 的激活，无论是通过其经典途径还是偏向途径，都会触发一系列信号级联反应，介导多种功能。本综述旨在强调 PAR2 在不同皮肤细胞中的新作用和相互作用。它特别总结了 PAR2 在特应性皮炎 (AD)、银屑病、白癜风和黄褐斑等皮肤疾病中的作用的最新见解。它还从与其他炎症性和自身免疫性皮肤病相关的皮肤微环境的角度考虑了这些作用。此外，该综述还探讨了 PAR2 在皮肤和皮肤外疾病相关合并症中的作用。因此，PAR2 可能是局部皮肤环境中各种细胞相互作用的关键靶点。
