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五齿和六齿吡啶并环配体支持可逆的Cu(II)/Cu(I)氧化还原对。

Pentadentate and Hexadentate Pyridinophane Ligands Support Reversible Cu(II)/Cu(I) Redox Couples.

作者信息

Blade Glenn, Wessel Andrew J, Terpstra Karna, Mirica Liviu M

机构信息

Department of Chemistry, University of Illinois Urbana-Champaign, 600 S. Matthews Ave, Urbana, IL 61801, USA.

Department of Chemistry, Washington University, One Brookings Drive, St. Louis, MO 63130, USA.

出版信息

Inorganics (Basel). 2023 Nov;11(11). doi: 10.3390/inorganics11110446. Epub 2023 Nov 20.

DOI:10.3390/inorganics11110446
PMID:39301085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11412068/
Abstract

Two new ligands were synthesized with the goal of copper stabilization, N,N'-(2-methylpyridine)-2,11-diaza3,3pyridinophane (N4) and N-(methyl),N'-(2-methylpyridine)-2,11-diaza3,3pyridinophane (N4), by selective functionalization of N4 and N4. These two ligands, when reacted with various copper salts, generated both Cu(II) and Cu(I) complexes. These ligands and Cu complexes were characterized by various methods, such as NMR, UV-Vis, MS, and EA. Each compound was also examined electrochemically, and each revealed reversible Cu(II)/Cu(I) redox couples. Additionally, stability constants were determined via spectrophotometric titrations, and radiolabeling and cytotoxicity experiments were performed to assess the chelators relevance to their potential use in vivo as Cu PET imaging agents.

摘要

为了实现铜的稳定化，通过对N4和N4进行选择性功能化，合成了两种新的配体，即N,N'-(2-甲基吡啶)-2,11-二氮杂3,3吡啶并环（N4）和N-(甲基),N'-(2-甲基吡啶)-2,11-二氮杂3,3吡啶并环（N4）。这两种配体与各种铜盐反应时，生成了Cu(II)和Cu(I)配合物。这些配体和铜配合物通过多种方法进行了表征，如核磁共振（NMR）、紫外可见光谱（UV-Vis）、质谱（MS）和元素分析（EA）。每种化合物还进行了电化学研究，结果显示均存在可逆的Cu(II)/Cu(I)氧化还原对。此外，通过分光光度滴定法测定了稳定常数，并进行了放射性标记和细胞毒性实验，以评估这些螯合剂作为铜正电子发射断层扫描（PET）成像剂在体内潜在应用的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64d0/11412068/f94307d2cbb9/nihms-2022023-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64d0/11412068/de0a54ef73c8/nihms-2022023-f0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64d0/11412068/1b97c4be1e4f/nihms-2022023-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64d0/11412068/362e8f1e982e/nihms-2022023-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64d0/11412068/f94307d2cbb9/nihms-2022023-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64d0/11412068/de0a54ef73c8/nihms-2022023-f0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64d0/11412068/e2d6fc78527e/nihms-2022023-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64d0/11412068/f1ede46a989d/nihms-2022023-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64d0/11412068/d3bec9b03b75/nihms-2022023-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64d0/11412068/1b97c4be1e4f/nihms-2022023-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64d0/11412068/362e8f1e982e/nihms-2022023-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/64d0/11412068/f94307d2cbb9/nihms-2022023-f0009.jpg

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