Seraji Amir Abbas, Nahavandi Reza, Kia Amir, Rabbani Doost Ahad, Keshavarz Vahid, Sharifianjazi Fariborz, Tavamaishvili Ketevan, Makarem Dorna
Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada.
Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran.
Front Bioeng Biotechnol. 2024 Sep 5;12:1417440. doi: 10.3389/fbioe.2024.1417440. eCollection 2024.
Bone structures facilitate the regeneration and repair of bone tissue in regions where it has been damaged or destroyed, either temporarily or permanently. Therefore, the bone's fatigue strength and durability are crucial to its efficacy and longevity. Several variables, such as the construct's material qualities, design, and production procedure, loading and unloading cycles, and physiological conditions influence the endurance life of bone constructs. Metals, ceramics, and polymers are all routinely utilized to create bone substitutes, and each of these materials has unique features that might affect the fatigue strength and endurance life of the final product. The mechanical performance and capacity to promote bone tissue regeneration may be affected by the scaffold's design, porosity, and pore size. Researchers employ mechanical testing under cyclic loading circumstances as one example of an experimental approach used to assess bone construction endurance. These analyses can give us important information about the stress-strain behavior, resistance to multiple loading cycles, and fatigue strength of the new structure. Predicting the endurance life of the developed construct may also be possible with the use of simulations and numerical analyses. Hence, in order to create reliable and efficient constructs for bone tissue engineering, it is crucial to understand their fatigue strength and durability. The purpose of this study is to analyze the effective parameters for fatigue strength of bone structures and to gather the models and evaluations utilized in endurance life assessments.
骨结构有助于在骨组织暂时或永久受损或破坏的区域实现骨组织的再生和修复。因此，骨的疲劳强度和耐久性对其功效和寿命至关重要。几个变量，如构建体的材料特性、设计和生产过程、加载和卸载循环以及生理条件，都会影响骨构建体的耐久寿命。金属、陶瓷和聚合物都经常被用于制造骨替代物，并且这些材料中的每一种都具有可能影响最终产品疲劳强度和耐久寿命的独特特性。支架的设计、孔隙率和孔径可能会影响其促进骨组织再生的力学性能和能力。研究人员采用循环加载情况下的力学测试作为用于评估骨构建体耐久性的实验方法的一个例子。这些分析可以为我们提供有关新结构的应力 - 应变行为、对多次加载循环的抗性以及疲劳强度的重要信息。使用模拟和数值分析也可能预测所开发构建体的耐久寿命。因此，为了创建用于骨组织工程的可靠且高效的构建体，了解它们的疲劳强度和耐久性至关重要。本研究的目的是分析影响骨结构疲劳强度的有效参数，并收集耐久寿命评估中使用的模型和评估方法。
