Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Kermanshah University of Medical Sciences, Kermanshah, Iran.
Prostaglandins Other Lipid Mediat. 2024 Oct;174:106872. doi: 10.1016/j.prostaglandins.2024.106872. Epub 2024 Jul 21.
Several studies indicated the ameliorating effects of flaxseed supplementation on apolipoproteins, although others have conflicting results. Therefore, the present research was conducted in order to accurately and definitively understand the effect of flaxseed on apolipoproteins in adults. All articles published up to Juan 2024 were systematically searched through PubMed, Scopus, Embase, and Web of Science to collect all randomized clinical trials (RCTs). A random effects model was used to measure the combined effect sizes. Also, standardized mean difference (SMD) and 95 % confidence interval (CI) were used to report the combined effect size. Our results showed that flaxseed supplementation significantly reduced apo-BI (SMD: -0.57; 95 % CI: -0.95, -0.19, p = 0.003; I = 83.2 %, heterogeneity p < 0.001) and lipo(a) decreased (SMD: -0.34; 95 % CI: -0.59, -0.09, p=0.007; I=30.3 %, heterogeneity p=0.197). However, flaxseed did not change apo-AI levels (SMD: -0.37; 95 % CI: -0.87, 0.13, p = 0.146; I = 89.2 %, p-heterogeneity < 0.001). This meta-analysis has shown that flaxseed supplementation may have beneficial effects on apolipoproteins. Future high-quality, long-term clinical trials are needed to confirm our results.
几项研究表明，亚麻籽补充剂对载脂蛋白具有改善作用，尽管其他研究结果存在矛盾。因此，本研究旨在准确和明确地了解亚麻籽对成年人载脂蛋白的影响。通过 PubMed、Scopus、Embase 和 Web of Science 系统地搜索了截至 2024 年 1 月发表的所有文章，以收集所有随机临床试验 (RCT)。使用随机效应模型来衡量合并效应大小。还使用标准化均数差 (SMD) 和 95%置信区间 (CI) 来报告合并效应大小。我们的研究结果表明，亚麻籽补充剂显著降低了载脂蛋白 BI (SMD: -0.57; 95%CI: -0.95, -0.19, p = 0.003; I = 83.2%, 异质性 p < 0.001) 和脂蛋白 (a) (SMD: -0.34; 95%CI: -0.59, -0.09, p=0.007; I=30.3%, 异质性 p=0.197)。然而，亚麻籽并没有改变载脂蛋白 AI 水平 (SMD: -0.37; 95%CI: -0.87, 0.13, p = 0.146; I = 89.2%, p-异质性 < 0.001)。这项荟萃分析表明，亚麻籽补充剂可能对载脂蛋白具有有益的影响。需要进行高质量、长期的临床试验来证实我们的结果。
