Shahid Mahek, Ibrahim Ramzi, Olagunju Abdulbaril, Mookadam Martina, Mookadam Farouk
Department of Medicine, University of Arizona Tucson, Tucson, Arizona, United States.
Sarver Heart Center, University of Arizona Tucson, Tucson, Arizona, United States.
Curr Cardiol Rev. 2025;21(1):e1573403X318646. doi: 10.2174/011573403X318646240909072055.
Heart failure with preserved ejection fraction (HFpEF) includes almost half of heart failure cases typified by a specific clinical syndrome. Despite diagnostic and management advances, HFpEF still presents a diagnostic challenge and a paucity of therapies specifically aimed at enhancing survival and improving quality of life is still lacking. This review elucidates the diagnostic complexity of HFpEF, highlighting the use of both subjective and objective criteria within algorithmic frameworks. It also examines the significant impact of comorbidities on the progression of HFpEF. Additionally, we explore the latest evidence on targeting these comorbidities therapeutically, although the benefits to mortality are still limited.
射血分数保留的心力衰竭（HFpEF）占心力衰竭病例的近一半，以特定临床综合征为典型特征。尽管在诊断和管理方面取得了进展，但HFpEF仍然存在诊断挑战，并且仍然缺乏专门旨在提高生存率和改善生活质量的治疗方法。本综述阐明了HFpEF的诊断复杂性，强调在算法框架内使用主观和客观标准。它还研究了合并症对HFpEF进展的重大影响。此外，我们探讨了针对这些合并症进行治疗的最新证据，尽管对死亡率的益处仍然有限。
