Mehrizi Tahereh Zadeh, Rezayat Seyed Mahdi, Shahmabadi Hasan Ebrahimi
Vaccine Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Curr Drug Deliv. 2025;22(5):537-551. doi: 10.2174/0115672018316266240909075316.
A wide range of challenges are faced during the storage of blood products, including storage lesions, contamination that must be removed, and cell and protein damage due to chemicals and UV exposure. The enhancement of stability exhibited by gold nanoparticles (GNPs) is a notable advantage of these nanoparticles for the storage of blood products. The results of our review of articles from 2011 to 2022 discussing the effect of GNPs on blood products revealed that in RBCs, the dose, concentration, amount, and surface charge of GNPs significantly affect their compatibility. Purified GNPs were compatible with RBCs. Negatively charged GNPs with smaller diameters at lower concentrations were more compatible. However, in the plasma product, the nanoparticle surface modification with different agents showed greater compatibility. PEGylated nanospheres and GNPs exhibited higher albumin conformational stability than those coated with cetyltrimethylammonium bromide and rods. In the platelet product, smaller GNPs and high GNP concentrations induce platelet aggregation. PEGylation increased the platelet compatibility of GNP. The combination of GNPs with human fibrinogen and clopidogrel prevented clot formation. Finally, the findings of this investigation demonstrate that GNPs are contingent on their surface charge, dosage, and concentration.
在血液制品储存过程中面临着一系列广泛的挑战，包括储存损伤、必须去除的污染以及由于化学物质和紫外线暴露导致的细胞和蛋白质损伤。金纳米颗粒（GNPs）所表现出的稳定性增强是这些纳米颗粒用于血液制品储存的一个显著优势。我们对2011年至2022年讨论GNPs对血液制品影响的文章进行综述的结果表明，在红细胞中，GNPs的剂量、浓度、数量和表面电荷显著影响它们的相容性。纯化的GNPs与红细胞相容。较低浓度下直径较小的带负电荷的GNPs更具相容性。然而，在血浆制品中，用不同试剂进行的纳米颗粒表面修饰显示出更大的相容性。聚乙二醇化纳米球和GNPs比用十六烷基三甲基溴化铵包被的纳米球和纳米棒表现出更高的白蛋白构象稳定性。在血小板制品中，较小的GNPs和高GNP浓度会诱导血小板聚集。聚乙二醇化增加了GNP与血小板的相容性。GNPs与人类纤维蛋白原和氯吡格雷的组合可防止血栓形成。最后，这项研究的结果表明，GNPs取决于它们的表面电荷、剂量和浓度。
